REnal TrAIning & reteNtion (RETAIN) Program

 描述（由申请人提供）：这是一个新的申请T32响应NIDDK的要求，联合收割机肾病的T32，这是在其第27年，主任马克S。Segal MD/PhD主任，肾脏科和生理学T32，这是在其第五年，主任查尔斯伍德博士。是生理学和功能基因组学系主任。新计划的基本原理是，研究人员仍然迫切需要调查肾脏疾病的病因，发病机制，管理和后果。T32是独一无二的，因为它结合了生理学在产前编程方面的优势和肾脏学在转化研究方面的优势。该培训补助金的目的是为肾脏疾病费尔德的基础，转化或临床研究提供一流的培训。将为博士前（4名博士、药学博士或医学博士-博士生）和博士后（2名医学博士、博士或药学博士）学员提供2至3年的培训。该学院由临床科学家和基础科学家组成，他们的研究集中在对了解慢性肾脏疾病及其后遗症的基础非常重要的领域。博士前学员将通过医学院的生物医学科学（IDP）或药学院的跨学科项目进行招聘和培训。博士后培训生将通过T32计划教师和国家广告招募。所有学员将有一名主要导师、一名肾脏导师（如果主要导师不在肾脏科）和一名基础科学或流行病学导师。对于那些谁进入临床研究公共卫生学院的MPH可以获得。该T32计划的开发具有特定的机制，以加强合格人员的招聘转化研究，并帮助确保他们未来的成功。本案无关肥胖、代谢综合征和糖尿病流行的主要后果是患有肾病的患者急剧增加。目前有近3000万人患有不同程度的肾功能障碍，其中近80万人患有终末期或近终末期肾病。除此之外，近500万人在遭受急性肾损伤后出院，最近认识到这些人的发病率和死亡率风险增加，导致对肾脏研究的巨大需求。该培训补助金提供了一个重点计划，用于培训有前途的候选人进行基础，翻译和临床研究，这将有助于他们为肾脏病学的学术生涯做好准备。

 DESCRIPTION (provided by applicant): This is a new application for a T32 in response to NIDDK's request to combine Nephrology's T32, which was in its 27th year, director Mark S. Segal MD/PhD Chief, Division of Nephrology, and Physiology's T32, which was in its 5th year, director Charles Wood Ph.D. is the Chair of the Department of Physiology and Functional Genomics. The rationale for the new program is that there remains a critical need for researchers to investigate the etiologies, pathogenesis, management, and consequences of kidney diseases. This T32 is unique since it combines Physiology's strength in pre-natal programing with the Nephrology's strength in translational research. The objective of this training grant is to provide superb training in basic, translational, or clinical research in the feld of kidney diseases. Training will be provided to both predoctoral (4 PhD, PharmD, or MD- PhD students) and postdoctoral (2 MDs, PhDs, or PharmDs) trainees, for 2 to 3 years. The faculty consists of clinician-scientists and basic scientists whose research is concentrated in areas important for understanding the basis of chronic kidney disease and its sequelae. The predoctoral trainees will be recruited and trained through the College of Medicine's Interdisciplinary Program in Biomedical Sciences (IDP) or the College of Pharmacy. Postdoctoral trainees will be recruited through T32 program faculty and national advertising. All trainees will have a primary mentor, a renal mentor (if the primary mentor is not in the Division of Nephrology), and a basic science or epidemiologic mentor. For those who enter clinical research an MPH in the School of Public Health can be obtained. This T32 program was developed with specific mechanisms to enhance recruitment of qualified personal into translational research and to help ensure their future success. Relevance. A major consequence of the epidemic of obesity, metabolic syndrome, and diabetes has been a dramatic increase in patients suffering from kidney disease. Currently there are nearly 30 million individuals with variable degrees of kidney dysfunction, with nearly 800,000 with either end stage or near end stage kidney disease. Add to this the nearly 5 million individuals discharged from the hospital after suffering acute kidney injury and the recent realization that these individuals are increased risk for morbidity and mortality leads to a tremendous need for kidney investigation. This training grant provides a focused program for training promising candidates in basic, translational, and clinical research which should help them prepare for an academic career in nephrology.