2015 RNA Editing Gordon Research Conference & Gordon Research Seminar

 描述（由申请人提供）：遗传信息通常通过RNA或DNA编辑在核苷酸水平上改变。这种核酸修饰过程对于在从简单的原核生物到人类的许多生物系统中产生多样性至关重要。重要的是，RNA和DNA编辑和修饰过程在固定遗传信息灵活适应不断变化的条件（如生物和非生物胁迫、炎症、分化和感染）方面发挥着关键作用。此外，不同形式的RNA编辑是产生神经元可塑性和防御病原体或外源核酸的关键因素。因此，RNA编辑和修饰反应的改变对神经系统的正常功能、恶性肿瘤的起源和进展以及成功对抗包括艾滋病毒和其他病原体在内的感染性疾病具有深远的影响。2015年RNA编辑GRC和GRS的目的是提供一个论坛，介绍与RNA编辑功能相关的各种生物医学问题的前沿研究，促进具有不同专业知识的研究人员之间的强有力的互动，并在他们的职业生涯的不同阶段，加强跨学科方法的发展，以研究RNA和DNA编辑和修饰，并促进下一代的发展科学家（学生，博士后和初级研究人员）。总的来说，这些目标将促进跨学科的合作，从而产生新的研究方法，旨在了解宿主-病原体相互作用和疾病病因，最终改善受RNA和/或DNA编辑过程影响的多种人类疾病的治疗和诊断方法。

 DESCRIPTION (provided by the applicant): Genetic information is often altered at the nucleotide level by RNA or DNA editing. This nucleic acid modifying process is essential for generating diversity in numerous biological systems, from simple prokaryotes to humans. Importantly, RNA and DNA editing and modification processes play a critical role in the flexible adaptation of fixed genetic information to changing conditions such as biotic and abiotic stresses, inflammation, differentiation, and infection. Moreover, different forms of RNA editing are key factors to generate neuronal plasticity and in the defense against pathogens or foreign nucleic acids. Alterations in RNA editing and modification reactions therefore have a profound impact on proper function of the nervous system, the origin and progression of malignancies and the successful battle against infectious diseases including viruses such as HIV and other pathogens. The aims of the 2015 RNA Editing GRC and GRS are to provide a forum for the presentation of cutting edge research on diverse biomedical problems that are functionally related to RNA editing, to promote strong interactions between researchers with different expertise and at different stages in their careers, to enhance the development of interdisciplinary approaches to studying RNA and DNA editing and modification and to foster the development of the next generation scientists (students, post-docs, and junior investigators). Collectively these goals will promote cross-disciplinary collaborations that will result in new research approaches aimed at understanding host-pathogen interactions and disease etiology that will ultimately lead to improved methods for the treatment and diagnosis of multiple human diseases impacted by RNA and/or DNA editing processes.