Southern California Research Center for ALPD and Cirrhosis

描述（由申请人提供）：酒精性肝脏和胰腺疾病（ALPD）和肝硬化是全球主要的生活方式疾病。南加州阿尔茨海默病和肝硬化研究中心联合了来自南加州主要学术机构的57名研究人员，共同致力于成为阿尔茨海默病研究、培训和推广的领导者。自1999年成立以来，该中心一直致力于开发和使用临床相关的动物模型，以获得对晚期ALPD易感性的分子机制的新见解。这些努力最终导致了最近的突破性发现，这些发现大大提高了我们对酒精和二次打击引起的协同ALPD的理解。该中心的互动环境和基础设施在过去5年中得到了便利，研究基地增长了152%，达到850万美元/年；4个新的UOl/POI程序；198的出版物;14位美国国立卫生研究院资助的早期研究人员；8名博士后转为教师；培训毕业生166名

DESCRIPTION (provided by applicant): Alcoholic liver and pancreatic diseases (ALPD) and cirrhosis constitute leading life-style diseases around the globe. The Southern California Research Center for ALPD and Cirrhosis unifies 57 investigators from major academic institutions in Southern California to pursue a common mission of being a leader in research, training, and outreach for the diseases. The center, since its inception in 1999, has devoted its efforts for development and use of clinically relevant animal models to gain novel insights into the molecular mechanisms underlying the predisposition to advanced ALPD. These efforts culminated to recent groundbreaking discoveries which have significantly advanced our understanding of synergistic ALPD caused by alcohol and a second hit. The center's interactive environment and infrastructure have facilitated in the past 5 years, a 152% increase in research base to $8.5M/year; 4 new UOl/POI programs; 198 publications; generation of 14 NIH-funded early-stage investigators; transition of 8 postdocs to faculty positions; training 166 graduate and 20 undergraduate students; and organizing 3 community seminars and 4 international symposia. As a unique national resource, the center has provided to scientific communities across the nation: 229 rodents as ALPD models and 241 model samples for 17 outside investigators; 329 liver cell isolation preparations for 14 investigators; and support for grant acquisition and application by 12 outside investigators since the last renewal. The center will continue to strive as a unique scientific center of excellence in ALPD and cirrhosis by promoting: 1) environment conducive for leading-edge research on the center's theme: elucidation of the priming and sensitizing mechanisms for ALPD; 2) provision of unique models, innovative genetic approaches and expertise to outside investigators including those at other NIAAA Alcohol Research Centers; 3) comprehensive education and training to foster future generations of scientists in ALPD and cirrhosis; and 4) outreach efforts to disseminate the center's new findings to lay public, health care workers and scientists in our home and global communities.