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Cerebral Protein Synthesis as a Measure of Degenerative Changes in a Transgenic Rat Model of Alzheimers Disease

Cerebral Protein Synthesis as a Measure of Degenerative Changes in a Transgenic Rat Model of Alzheimers Disease
脑蛋白合成作为阿尔茨海默病转基因大鼠模型退行性变化的测量
批准号：
9152143
负责人：
CAROLYN B. SMITH
金额：
$20.36万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9152143
关键词：
Age-MonthsAlzheimer&aposs DiseaseAlzheimer&aposs disease modelAmyloid beta-ProteinAmyloid beta-Protein PrecursorAmyloidosisAnimalsApoptoticAppearanceBehaviorBiological MarkersBreedingCerebral cortexCerebrumDepositionDeteriorationDiseaseDisease ProgressionEarly Onset Familial Alzheimer&aposs DiseaseFoodFundingGenesGliosisHippocampus (Brain)HumanImpaired cognitionLearningMeasuresMemoryMethodsModelingPerformancePositron-Emission TomographyProcessProtein BiosynthesisRattusSleepSmell PerceptionStagingTauopathiesTestingTimeTransgenic ModelTransgenic OrganismsTreatment EfficacyUnited States National Institutes of Healthage relatedcerebral atrophycohorthuman diseasehuman subjectmutantneuron lossnovelopen field behaviorpresenilin-1

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中文摘要
翻译
在2015年的资助期间，我们在NIH建立了这种转基因模型的繁殖群体，我们已经开始研究用放射自显影L-1-C-14亮氨酸方法测量WT和TgF 344-AD队列中6个月、14个月和18个月龄的rCPS。 在这些动物中，我们还通过开放领域行为来测量活动，通过T-迷宫来测量记忆，通过埋藏食物任务来测量嗅觉，以及在同一时间点测量睡眠行为。在另一组纵向研究的动物中，我们用L-1-C-11亮氨酸PET方法测量rCPS。
英文摘要
During the 2015 funding period, we established a breeding colony of this transgenic model at the NIH and we have begun studies to measure rCPS with the autoradiographic L-1-C-14leucine method in cohorts of WT and TgF344-AD at six, 14, and 18 months of age. In these animals we are also measuring activity by means of open field behavior, memory by means of the T-maze, olfaction by means of the buried food task, and sleep behavior at the same time points. In a separate cohort of animals studied longitudinally we are measuring rCPS with the L-1-C-11leucine PET method.
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STUDIES ON PROTEIN SYNTHESIS AND AMINO ACID COMPARTMENTATION
DEVELOPMENT, INVOLUTION AND PLASTICITY IN THE CENTRAL NERVOUS SYSTEM
Mathematical and Statistical Analysis Techniques for in Vivo Imaging Studies
Cerebral Protein Synthesis During Sleep and Memory Consolidation