Pittsburgh Intensive Training in Hematology Research

 描述（由申请人提供）：本申请的目标是通过在匹兹堡大学提供与血液科学相关的创新技术和概念范式（特别是溶血相关血管生物学）方面为期6个月的教育和培训经验，丰富血液学研究人员队伍。匹兹堡血液学研究计划强化培训的重点是为研究生，博士后科学家和初级教师研究人员提供实验和转化血液学培训。其目标是通过实验和转化血液学的指导教学和动手实践课程，结合试点研究项目，在培养血液学科学家的关键阶段提高技能发展。它主要针对需要学习专门血液学技术的攻读博士学位的研究生，对血液科学感兴趣的早期博士后，他们需要一个强化课程来促进血液学研究的职业转变，以及对发展职业有浓厚兴趣的初级教师研究人员在基础和转化镰状细胞病研究。共 23匹兹堡大学的学术核心教师来自匹兹堡大学的血液学/肿瘤学，血管生物学，分子生物学，药理学，凝血和血栓形成，输血医学和再生医学等广泛学科，可提供广泛的基础和转化研究课题，并研究患者人群以开展本项目。该计划侧重于血液学研究的多个领域，包括溶血相关的血管疾病，镰状细胞病，血红素和铁代谢和信号，造血干细胞和iPS。培训将包括学习应用于临床问题的尖端血液学方法，从而为患者提供潜在的新型治疗方法或临床研究。学员将从各种先进的血液学研究技术中进行选择，并可以选择在血栓形成方面进行实习，以及在非洲进行以患者为导向的镰状细胞实习，在大型患者群体中工作。(End摘要）

 DESCRIPTION (provided by applicant): The goal of this application is to enrich the hematology research workforce through the provision of a six-month educational and training experience in innovative technologies and conceptual paradigms related to blood science, in particular hemolysis-related vascular biology, at the University of Pittsburgh. The focus of the Pittsburgh Intensive Training in Hematology Research Program is training in experimental and translational hematology for graduate students, postdoctoral scientists, and junior faculty investigators. Its objective is to enhance skills development at key stages of the training of bloo scientists through a mentored didactic and hands-on practical course in experimental and translational hematology coupled with a pilot research project. It is intended primarily for graduate students pursuing PhD degrees who need to learn a specialized hematologic technique, early-stage postdocs interested in blood science who need an intensive course to catalyze a career switch to hematological research, and junior faculty investigators with a strong interest in developing a career in basic and translational sickle cell disease research. A total of 23 University of Pittsburgh academic core faculty from the broad disciplines of hematology/oncology, vascular biology, molecular biology, pharmacology, coagulation and thrombosis, transfusion medicine, and regenerative medicine at the University of Pittsburgh are available to provide a broad array of basic and translational research topics and study patient populations to carry out this project. The program is focused on multiple areas of hematology research including hemolysis-related vascular disorders, sickle cell disease, heme and iron metabolism and signaling, hematopoietic stem cell and iPS. Training will incorporate the learning of cutting edge hematologic methodologies that is applied to a clinical problem, leading to potentially novel therapeutic approaches or clinical studies in patients. Trainees will choose from a variety of advanced research hematology techniques and will have the option to pursue internship in thrombosis, and a patient-oriented sickle cell internship in Africa working on large patient cohorts. (End of Abstract)