Consortium for the Study of Pancreatitis: Pittsburgh Clinical Center

 描述(申请人提供)：匹兹堡临床中心(PCC)是匹兹堡大学和UPMC的一个临床-翻译项目，旨在对复发性急性胰腺炎(RAP)和慢性胰腺炎(CP)以及儿童和成人中增加纤维化、疼痛和胰源性糖尿病(T3cDM)风险的因素，以及患有CP和/或DM的成人中的胰腺导管腺癌(PDAC)风险进行研究。匹兹堡大学和UPMC组织了多学科团队，参与胰腺疾病患者的全面临床、流行病学和生物学特征研究，并 明确RAP和CP的病理生理学及其后遗症。提出了三个具体目标：目标1。开发综合临床中心核心流程，以促进数据和生物样本管理，最大限度地加强沟通，并对新技术进行评估。目的2.建立明确慢性阻塞性肺疾病演变过程中的模型纵向研究队列。目的3.建立和测试一个框架，以分析影响RAP进展的危险因素、可能的CP和明确的CP，以及临床上有用的监测疾病状态和终点的生物标志物。我们现有的完善、高效和有效的临床基础设施将支持该计划，这些基础设施用于患者积累、样本处理、疾病进展评估、数据管理和分析。丰富的临床数量，所有关键领域的内科专家表型，在流行病学、遗传学、生理学、细胞生物学、成像、生物统计学和生物信息学以及所有相关疾病亚型方面的领先地位，加上成人和儿童临床和研究领域的行政权力，确保了持续的成功。PCC教员与其他大学许多优秀项目的密切合作和工作关系的历史也将为国家联盟提供动力。

 DESCRIPTION (provided by applicant): Pittsburgh Clinical Center (PCC) is a clinical-translational program at the University of Pittsburgh and UPMC designed to conduct studies on recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) and factors that increase the risk of fibrosis, pain, and pancreatogenic diabetes (T3cDM) in children and adults, and risk of pancreatic ductal adenocarcinoma (PDAC) in adults with CP and/or DM. Multi-disciplinary teams at the University of Pittsburgh and UPMC are organized to participate in comprehensive clinical, epidemiological and biological characterization of patients with pancreatic disorders and to define the pathophysiology of RAP & CP and their sequela. Three specific aims are proposed: Aim 1. To develop integrated clinical center core processes to facilitate data and biosample management, to maximize communication and to evaluate of new technologies. Aim 2. To establish a model longitudinal research cohort of patients during evolution of definite CP. Aim 3. To generate and test a framework to analyze risk factors affecting the progression of RAP, probable CP and definite CP, and clinically useful biomarkers to monitor disease state and endpoints. Our existing and well-established, efficient and effective clinical infrastructure for patient accrual, sample processing, disease progression assessment, data management and analysis will support the program. The rich clinical volume, expert physician phenotypers in all critical areas, established leadership in epidemiology, genetics, physiology, cell biology, imaging, biostatistics and bioinformatics, and all relevant disease subtypes, plus administrative authority in clinical and research areas for both the adult and children ensure continued success. The history of strong collaborations and working relationships of the PCC faculty with many outstanding programs at other universities will also provide momentum to the national consortium.