2020 Molecular & Cellular Neurobiology Gordon Research Conference and Gordon Research Seminar

项目摘要 2020年戈登分子和细胞神经生物学研究会议将汇集 来自学术界和工业界的神经科学家讨论了神经系统研究的最新突破， 系统最近的技术创新，包括光遗传学，基因组编辑，组织清除，超 分辨率显微镜和单细胞测序使大脑的研究以前所未有的速度发展。 详细程度。科学会议将突出神经系统发展的最新发现， 突触功能，行为背后的神经回路，脑成像和连接组学，以及分子和 神经系统疾病的细胞机制，包括神经变性和神经精神障碍。一 这次国际会议的主要目标是促进各级科学家之间的互动， 不同的背景，以刺激新的合作和神经科学研究的方向。 在科学会议和留出的非正式会议期间，都将鼓励讨论 交互.为了促进下一代神经科学家，将从摘要中选择简短的谈话 由学生、博士后研究员和初级教员提交。GRC还将推出Power Hour， 所有与会者的非正式会议，讨论妇女在科学领域面临的挑战，并支持专业人员 通过提供一个公开的讨论和指导论坛，促进妇女的成长。最后，这一集将在 由戈登研究研讨会（GRS）的分子和细胞神经生物学，这将是一个主题演讲 演讲者，只对学生和博士后开放。GRS将作为学员的论坛， 扩大他们的同行网络，并将补充GRC，汇集来自世界各地的科学家 讨论和确定分子和细胞神经生物学的新方向。最近技术的爆炸 神经科学的进步使神经科学家能够研究基础和转化神经科学， 前所未有的细节。例如，光遗传学已经提供了关于何时以及如何激活一个 所选择的神经元或神经回路引起生理或病理效应。iPSC技术使其 从病人身上分离体细胞，并产生神经和精神疾病的“细胞模型”， 通过将这些细胞分化（或直接转化）为精确类型的神经元和神经胶质来治疗疾病。Genomics 和蛋白质组学允许识别易感基因和复杂的信号网络的全局视图。 表观遗传学研究可能揭示突触可塑性、学习记忆的新编码机制。基因组 使用CRISPR/Cas9进行编辑在生成用于建模研究的特定突变方面都是革命性的 以及用于在人类细胞和神经元中进行全基因组修饰物筛选。最近，单细胞 测序揭示了大脑中的新型细胞和新的细胞状态，并使研究 全脑连接组学该领域的主要研究人员将提出这些前沿问题及其 会议将讨论所涉问题。

Project Summary The 2020 Gordon Research Conference on Molecular and Cellular Neurobiology will bring together neuroscientists from academia and industry to discuss the latest breakthroughs in the study of the nervous system. Recent technological innovations, including optogenetics, genome editing, tissue clearing, super resolution microscopy, and single cell sequencing have empowered the study of the brain at an unprecedented level of detail. Scientific sessions will highlight recent discoveries on the development of the nervous system, synaptic function, neural circuits underlying behavior, brain imaging and connectomics, and molecular and cellular mechanisms of neurological diseases, including neurodegenerative and neuropsychiatric disorders. A major goal of this international conference will be to foster interactions among scientists at all levels and from different backgrounds in order to stimulate new collaborations and directions of neuroscience research. Discussion will be encouraged both in the scientific sessions as well as during time set aside for more informal interactions. To promote the next generation of neuroscientists, short talks will be selected from abstracts submitted by students, postdoctoral fellows and junior faculty members. The GRC will also feature a Power Hour, an informal session for all attendees to discuss challenges women face in science and to support the professional growth of women by providing an open forum for discussion and mentoring. Finally, this GRC will be preceded by a Gordon Research Seminar (GRS) on Molecular and Cellular Neurobiology, which will feature a keynote speaker and be open only to students and postdoctoral fellows. The GRS will serve as a forum for trainees to broaden their peer network and will complement the GRC in bringing together scientists from around the world to discuss and identify new directions in molecular and cellular neurobiology. An explosion in recent technological advances has empowered neuroscientists to examine fundamental and translational neuroscience in unprecedented detail. For example, optogenetics has provided insight into when and how the activation of a selected neuron(s) or neural circuit causes physiological or pathological effects. iPSC technology makes it possible to isolate somatic cells from patients and generate “cell models” of neurological and psychiatric disorders by differentiating (or directly converting) these cells into precise types of neurons and glia. Genomics and proteomics allow for identification of susceptibility genes and a global view of intricate signaling networks. Epigenetic studies may reveal a novel coding mechanism of synaptic plasticity, learning and memory. Genome editing using CRISPR/Cas9 has been revolutionary in both generating specific mutations for modeling studies and for performing genomewide modifier screens in human cells and neurons. Most recently, single cell sequencing is revealing novel types of cells in the brain and novel cell states and is empowering the study of whole brain connectomics. The leading researchers in the field will present these cutting-edge issues and their implications will be discussed at the meeting.