2022 Membrane Transport Proteins GRC/GRS

项目摘要 2020年戈登膜转运蛋白研究会议题为“生物医学转运蛋白： 生理学，功能障碍和药物治疗的目标”将带来迫切需要的翻译重点， 临床相关和高度可药用的膜转运蛋白的研究。虽然他们占10%的 人类基因组和思维也导致了一系列高度流行的疾病（自闭症、抑郁症、糖尿病）， 作为孤儿和罕见疾病（Christianson综合征、粘蛋白沉积症），膜转运蛋白仍然主要 它们作为治疗靶点的潜力以及它们与特定疾病的关联尚未被探索。推动力在 组织这次会议 是将遗传、分子和机制的见解联系起来， 转运蛋白，包括载体，离子通道和泵，以生理功能和疾病相关 故障其目的是提供和讨论药物治疗的发展机会， 疾病状态下的转运蛋白功能障碍。N 一系列高度跨学科的科学会议正在汇集 与传统无关的主题、方法和新想法。这些包括从遗传学的转运蛋白 和离子通道在疾病状态下，非传统的动物模型，研究转运，或特别是 单分子荧光共振能量转移和经颅磁共振等方法 刺激.这可以防止人们认为某个特定的方法或主题主导了会议， 扩大了讨论新想法的机会。引入了新的主题（如肽，激素， 和神经递质的释放：转运蛋白在肠道和大脑中的重要性;无脊椎动物作为动物模型 研究转运蛋白功能等）这是本次会议从未涉及的。充足的讨论时间 每次演讲后，每天的海报和下午的自由时间允许进行非正式讨论，建立网络和形成新的 合作。2020年会议的其他特别功能包括戈登研究研讨会的年轻 研究人员，以及促进女科学家的权力小时。值得一提的是我们保护了伊莫金·科医生 作为《活力一小时》的讨论领袖科博士是国际公认的加拿大思想领袖 在科学、技术、工程和数学（STEM）领域的公平、多样性和包容性（EDI）。她 为学术界、政府和工业界提供了关于改进STEM领域EDI的最佳实践和方法的建议， 特别是在加拿大高等教育（PSE）部门。她写过这些，也说过这些。 为地球仪和Mail、iPolitics和CBC等平台提供广泛的问题。2016年，她被公认为 加拿大百大女性之一，因为她在促进STEM平等方面的倡导工作。我们觉得这 会议将提供大量的科学机会，促进以EDI为中心的环境。

PROJECT SUMMARY The 2020 Gordon Research Conference on Membrane Transporter Proteins titled “Biomedical Transporters: Physiology, Dysfunction and Targets of Pharmacotherapy” will bring an urgently needed translational focus to research on clinically relevant and highly druggable membrane transporters. Although they account for 10% of the human genome and thought contribute to a gamut of highly prevalent (autism, depression, diabetes) as well as orphan and rare diseases (Christianson syndrome, mucoviscidosis), membrane transporters remain largely unexplored in their potential as therapeutic targets, and in their association to specific diseases. The impetus in organizing this conference is to link genetic, molecular and mechanistic insights on clinically important membrane transporters, including carriers, ion channels and pumps, to physiological function and disease-related malfunction. The intent is to offer and discuss opportunities for the development of pharmacotherapies targeting transporter dysfunctions in disease states. N ine highly interdisciplinary scientific sessions are bringing together topics, approaches and novel ideas that are not conventionally related. These range from genetics of transporter and ion channels in disease states, to unconventional animal models to study transporter, or particular approaches such as single-molecule fluorescence resonance energy transfer and transcranial magnetic stimulation. This prevents the perception of a particular approach or topic dominating the conference and amplifies opportunities for discussion of new ideas. New topics have been introduced (e.g. peptides, hormones, and neurotransmitter release: the importance of transporters in the gut and brain; invertebrates as animal models to study transporter functions, etc.) that have never been covered in this conference. Ample discussion time after each talk, daily posters, and afternoon free time allow for informal discussion, networking and forming new collaborations. Other special features of the 2020 conference include the Gordon Research Seminar for young investigators, and the Power Hour for the promotion of women scientists. Notably, we secured Dr. Imogen Coe as the Discussion Leader of the Power Hour. Dr. Coe is internationally recognized as a Canadian thought leader in the area of equity, diversity and inclusion (EDI) in science, technology, engineering and math (STEM). She has advised academia, government and industry on the best practices and approaches to improve EDI in STEM, particularly in the Canadian post-secondary education (PSE) sector. She has written and spoken about these issues extensively for platforms such as the Globe and Mail, iPolitics and the CBC. In 2016, she was recognized as one of Canada's Top 100 Women for her advocacy work promoting equity in STEM. We feel that this conference will offer plenty of scientific opportunities fostering an environment centered on EDI.