Clinical Pharmacoepidemiology Training Grant

项目摘要 生物统计、流行病学和信息学系(DBEI)，临床流行病学中心 和生物统计学(CCEB)和药物流行病学研究和培训中心(CPeRT) 宾夕法尼亚大学佩雷尔曼医学院提交续签申请以继续 并改进我们创新的、非常成功的临床药学博士后培训计划- 流行病学。药物流行病学是研究药物和其他药物的使用和效果的学科。 产品在人群中。我们的培训计划吸引了来自全国各地的高素质临床医生。 这项为期两到三年的强化临床研究培训计划旨在：1)培训临床医生 严谨和独立的调查人员能够阐述研究问题并使用广泛的 药物流行病学方法来回答这些问题；2)提供对基本的 临床药理学原理；3)在导师的指导下提供密集的、受监督的研究经验 临床药物流行病学和其他内容领域的导师；以及4)加强临床药物流行病学和其他内容领域导师之间的联系 流行病学和临床药理学。为了学习临床研究的基础科学，研究员进入 我们非常成功的临床流行病学理学硕士(MSCE)或流行病学博士学位 临床流行病学、药物流行病学、结果方面的课程和必修课程 测量、生物统计学和数据库管理；药物开发、药理学的选修课 以及与研究员的兴趣和经验相关的其他领域；独立阅读；以及参与 DBEI/CCEB和CPeRT内的研究研讨会和其他活动。这些技能适用于小学 培训计划的重点，即设计、实施、分析和发布指导 以他们的独立研究事业目标为目标的研究员设计的独立研究项目。 该计划的优势包括：1)大量经过临床培训的高素质应聘者 在药物流行病学方面寻求严格的研究培训；2)成功研究培训的悠久历史 DBEI/CCEB中的方案，包括药物流行病学和比较有效性 研究/以患者为中心的结果研究；3)全面的课程设置和研究计划 提供给研究员；4)项目主任和其他教职员工的成功培训记录。此外, CPeRT和其他CCEB教员的可用性，他们提供广泛的方法学专业知识 和临床学科；大量对研究项目和培训有用的流行病学数据库；广泛的 可用于临床研究的一系列专业分析能力(例如，临床试验、病例对照、队列、 自主设计)；以及教职员工对合作研究和培训的承诺，结合 为这个项目提供一个理想的环境。

Project Summary The Department of Biostatistics, Epidemiology, and Informatics (DBEI), the Center for Clinical Epidemiology and Biostatistics (CCEB) and the Center for Pharmacoepidemiology Research and Training (CPeRT) of the University of Pennsylvania (Penn) Perelman School of Medicine submit this renewal application to continue and improve our innovative and highly successful post-doctoral training program in clinical pharmaco- epidemiology. Pharmacoepidemiology is the study of the use and effects of medications and other medical products in populations. Our training program attracts highly qualified clinicians from across the nation. This two- to three-year intensive clinical research training program is designed to: 1) train clinicians to be rigorous and independent investigators able to formulate research questions and use a wide range of pharmacoepidemiologic approaches to answer those questions; 2) provide an understanding of the basic principles of clinical pharmacology; 3) provide intensive, supervised research experience with mentors in clinical pharmacoepidemiology and other content-area mentors; and 4) strengthen the links between clinical epidemiology and clinical pharmacology. To learn the basic sciences of clinical research, fellows matriculate in our highly-successful Master of Science in Clinical Epidemiology (MSCE) or PhD in Epidemiology degree programs and complete required courses in clinical epidemiology, pharmacoepidemiology, outcomes measurement, biostatistics, and database management; elective courses in drug development, pharmacology and other areas relevant to the fellows' interests and experience; independent readings; and participation in research seminars and other activities within DBEI/CCEB and CPeRT. These skills are applied to the primary focus of the training program, which is the design, implementation, analysis, and publication of mentored independent research projects of the fellow's design that targets their independent research career goals. Strengths of the program include: 1) the large pool of highly qualified candidates with clinical training seeking rigorous research training in pharmacoepidemiology; 2) the long history of successful research training programs in the DBEI/CCEB, including in pharmacoepidemiology and comparative effectiveness research/patient-centered outcomes research; 3) the comprehensive course offerings and research programs available to fellows; and 4) the successful training record of the program director and other faculty. In addition, the availability of the CPeRT and other CCEB faculty, who provide expertise in a wide range of methodologic and clinical disciplines; numerous epidemiologic databases useful for research projects and training; a broad array of specialized analytic capabilities available for clinical studies (e.g., clinical trials, case-control, cohort, self-controlled designs); and the faculty members' commitment to collaborative research and training, combine to provide an ideal environment for this program.