WormGuides: a resource for Global Understanding in Dynamic Embryonic Systems

描述（由申请人提供）：C。线虫是了解人类疾病的一个重要动物模型。生产力在C左右。系统级的有机体知识的产生和公开分享极大地促进了秀丽线虫的研究。在这里，我们提出了WormGUIDES（动态胚胎系统的全球理解），这是一种新的资源，将导致创建和共享任何动物的胚胎发生和神经发育的第一个图谱。WormGUIDES将产生从受精卵到孵化的核位置的交互式4D图谱。我们设想这将成为整个社区使用的日常参考工具，以指导细胞识别，量化发育过程并可视化胚胎中的新生模式和对称性。WormGUIDES还将为创建神经发育图谱提供技术渠道。C.线虫是唯一具有已知连接体的动物，通过WormGUIDES创建的工具将能够检查连接体在发育过程中如何出现。WormGUIDES将整合这些新生成的C语言知识。elegans胚胎发生，现有的和广泛使用的资源，如WormAtlas和WormBase。WormGUIDES的影响将是促进性的，它提供了一个全面的资源，使我们能够检查目前无法访问的神经发育方面，同时进一步加深我们对胚胎发生的理解，提高C的价值。elegans作为模式生物。

DESCRIPTION (provided by applicant): C. elegans is a key animal model for understanding a broad spectrum of human diseases. Productivity around C. elegans has been greatly facilitated by the generation and open sharing of systems-level knowledge of the organism. Here we propose WormGUIDES (Global Understanding in Dynamic Embryonic Systems), a novel resource that will result in the creation and sharing of the first atlas of embryogenesis and neurodevelopment for any animal. WormGUIDES will result in an interactive 4D atlas of nuclear positions, from zygote until hatching. We envision this will become an everyday reference tool used by the entire community to guide cell identification, quantify developmental processes and visualize nascent patterns and symmetries in the embryo. WormGUIDES will also result in a technical pipeline for the creation of a neurodevelopmental atlas. C. elegans is the only animal with a known connectome, and the tools created through WormGUIDES will enable examination of how this connectome emerges during development. WormGUIDES will integrate this newly generated knowledge of C. elegans embryogenesis to existing and widely used resources, such as WormAtlas and WormBase. The impact of WormGUIDES will be transfomative, providing a comprehensive resource that will enable examination of currently inaccessible aspects of neurodevelopment, while furthering our understanding of embryogenesis and enhancing the value of C. elegans as a model organism.