ReThink HF: A novel multi-parameter sensor for heart failure remote monitoring

描述（由申请人提供）：心力衰竭影响美国580万人，相关费用接近400亿美元。目前管理心力衰竭患者的临床范例是反应性的，涉及患者自我监测，其依从性较差。此外，患者缺乏测量相关生理指标的工具，医生对患者实时心脏状态的了解有限。我们的技术建议通过提供一种廉价的、无创的腕戴式监测器来解决这些问题，该监测器可以跟踪相关参数，向患者和医生办公室提供主动反馈，并且不需要患者的交互，从而产生高水平的依从性。该项目将研究一种新型的、无创的多参数传感器遥测监测心力衰竭患者的好处。该技术可以持续监测心率、心率变异性、呼吸频率、活动水平和体液水平。我们将把这些指标纳入一个经过验证的算法（在6个月内1200名患者住院率降低50%），用于早期检测心脏失代偿，目标是进一步提高算法的预测能力。我们的目标是简化心力衰竭的管理，同时提高患者的护理质量

DESCRIPTION (provided by applicant): Heart failure effects 5.8 million individuals in the US and the costs associated are approaching $40 billion. The current clinical paradigm for managing heart failure patients is reactive and involves patient self-monitoring which suffers from poor compliance. Additionally, patients lack the tools to enable measurements of the relevant physiologic metrics, and the physicians have limited insight of the patient's real-time cardiac status. Our technology proposes to solve these problems by providing an inexpensive, non-invasive wrist-worn monitor which tracks the relevant parameters, provides proactive feedback to the patient and physician's office, and requires no interaction from the patient thus yielding a high level of compliance. This project will investigate the benefits of a novel, non-invasive multi-parameter sensor with telemetry for monitoring patients with heart failure. The technology can continuously monitor heart rate, heart rate variability, respiratory rate, activity levels, and fluid levels. We will incorporate these metrics into a proven algorithm (50% reduction in hospitalizations in 1,200 patients over 6 months) for early detection of cardiac decompensation with a goal of further improving the predictive ability of the algorithm. Our goals are to simplify the management of heart failure while improving the quality of care of the patients and reducing the associated costs.