Aerobic Plus Resistance Training to Increase Insulin Sensitivity in African Ameri

描述(由申请人提供)：到目前为止，还没有一项大规模的随机对照研究来研究运动训练对非裔美国男性糖尿病风险因素(主要是胰岛素抵抗)的好处。国家标准化估计显示，20岁及以上的所有非裔美国人中有15%至20%患有糖尿病(包括确诊和未确诊的糖尿病)。有规律的体力活动是患糖尿病的一个可改变的危险因素。尽管已经证明，运动训练可以减少高加索成年人的糖尿病，但不能假设高加索成年人的益处也适用于其他种族的男性。这些类型的研究通常在大学环境中进行，与以社区为基础的项目相比，这可能是非裔美国人参与者的障碍。因此，我们建议在一个完全由非裔美国人组成的男性队列中，进行一项基于社区的随机试验，评估定期运动对糖尿病危险因素的影响。这项建议名为有氧加阻力训练，以增加非裔美国人男性的胰岛素敏感性(ARTIIS)。研究小组将由年龄在35岁至70岁之间、久坐不动、身体健康的非洲裔美国男性组成。在这个年龄段，我们正在招募患糖尿病风险最高的男性，因此，这一群体可能会从运动计划中受益。运动训练组的男性将进行150分钟的有氧运动，以及2天的力量训练。目标运动强度为最大摄氧量的50-70%(有氧)和50-80%的1RM(力量)。这一运动量与当前的国家体力活动建议是一致的，因此，ARTIIS将帮助确定当前的建议是否会对非裔美国男性的健康产生好处。我们认识到，非洲裔美国男性是一个很难接触到的群体。为了确保成功参与，我们将利用社区健身设施来提供该计划。因此，运动训练组的男性将能够在他们的社区进行运动。主要结果是糖尿病的危险因素，包括胰岛素对葡萄糖负荷的反应、空腹胰岛素和C-肽。次要结果是心血管健康、肌肉力量、体重和成分，以及心理结果。

DESCRIPTION (provided by applicant): To date, there has not been a large-scale, randomized, controlled study examining the benefits of exercise training the diabetes risk factor, mainly insulin resistance, in African American males. National standardized estimates show that between 15% and 20% of all African Americans aged twenty and older have diabetes (including both diagnosed and undiagnosed). Regular physical activity is a modifiable risk factor for the development of diabetes. Although it has been shown that exercise training results in a reduction of diabetes in Caucasian adults, it cannot be assumed that the benefits derived in Caucasian adults apply to men of other ethnic groups. These types of studies are typically conducted at the university setting, which can be a barrier for African American participants compared to a community-based program. Therefore, we proposed to a randomized community-based trial assessing the effect of regular exercise on risk factors for diabetes in an exclusively African American male cohort. This proposal is entitled Aerobic Plus Resistance Training to Increase Insulin Sensitivity in African American Men (ARTIIS). The study group will consist of sedentary, healthy African American men aged 35 to 70 years. At this age group, we are recruiting men who are at the highest risk of developing diabetes and therefore, the group who is likely to benefit from an exercise program. Males in the exercise training group will engage in 150 minutes of aerobic activity, as well as 2 days of strength training. The target exercise intensity is 50-70% of VO2 max (aerobic) and 50-80% of 1RM (strength). This exercise dose is consistent with the current national physical activity recommendations, and therefore, ARTIIS will assist in determining if the current recommendations result in health benefits for African American males. We recognize that African American males are a difficult-to-reach population. In order to ensure successful participation we will utilize community-based fitness facilities to deliver the program. Thus males in the exercise training group will be able to exercise in their community. Primary outcome measures are risk factors for diabetes including insulin response to a glucose load, fasting insulin, and c-peptide. Secondary outcomes are cardiovascular fitness, muscular strength, body weight and composition, and psychological outcomes.