Independent Scientist Award for Radiation Research

说明(申请人提供)：辐射暴露可通过医学成像和治疗、宇宙射线或氡的自然背景辐射以及通过辐射生物恐怖主义故意暴露而发生。这个独立科学家奖将让我有机会专注于利用基因工程小鼠剖析辐射反应和损伤机制的研究。最终，这些信息将为改进癌症治疗、太空探索和针对辐射的新对策奠定基础。 这项独立科学家(K02)奖将支持Kirsch博士利用小鼠遗传学来研究放射治疗的急性和迟发性效应的机制。这些体内研究将为设计安全有效的辐射对策提供机制基础，这些对策不会无意中增加辐射的后遗症。

DESCRIPTION (provided by applicant): Radiation exposure can occur from medical imaging and therapy, natural background radiation from cosmic rays or radon, and intentional exposure through radiation bioterrorism. This Independent Scientist Award will give me the opportunity to focus on research to dissect mechanisms of radiation response and injury by utilizing genetically engineered mice. Ultimately, this information will lay the groundwork for improved cancer therapy, space exploration, and novel countermeasures against radiation. This Independent Scientist (K02) award will support Dr. Kirsch to use mouse genetics to study mechanisms of acute and late effects from radiation therapy. These in vivo studies will provide a mechanistic foundation for the design of safe and effective countermeasures against radiation that do not inadvertently increase late effects of radiation.