ASSAY CORE

Core A测量项目1和项目2研究的患者的血清、血清超滤液（UF）、血浆和尿结石风险化学物质，并计算尿过饱和度（SS）。这些度量用于实现所有三个项目中的目标和在整个规划项目中执行的六个规划目标。项目1的血浆GLP-1、肾素、血浆和尿液cAMP也将由Core A测量。

Core A measures serum, serum ultrafiltrate (UF), plasma and urine stone risk chemistries and calculates urine supersaturations (SS) for patients studied in Projects 1 and 2. These measurements are used for fulfillment of aims within all three projects and six program aims carried out within the overall program project. Plasma GLP-1, renin, and plasma and urine cAMP will also be measured by Core A for Project 1. Blood and urine samples are processed and shipped for assay of lithium done in Core B and for measurement of plasma glucagon, parathyroid hormone (PTH) and 1,25 vitamin D (performed by LabCorp). Sample aliquots are stored at -80¿C for future use. All laboratory data from Core A for all projects are consolidated into a single database with daily backup for security and ease of analysis. Ultimately, data from the other projects and cores (e.g. histology, biopsy, stone analysis etc.) will be consolidated into our database so that it can be analyzed along with serum and urine data.