Hematopoiesis Training Grant

描述（由申请人提供）：本申请要求更新造血培训补助金，该补助金成立于1999年，旨在解决对造血和造血干细胞生物学有职业兴趣的科学家和医生科学家培训机会短缺的问题；并在这一不断发展的学科中为下一代提供核心的科学领导力。造血项目是一个多学科、跨部门的培训项目，利用宾夕法尼亚大学医学院（PSOM）、宾夕法尼亚儿童医院（CHOP）和Wistar研究所的广泛资源；从招收的各种博士预科和博士后项目的高素质学员中选拔任命人员；并包括具有广泛资助、出版和指导成就的教员培训师。培养博士、医学博士、博士-博士学位博士后17人、博士前5人，新增博士后3人、博士前3人。该计划从PSOM的大型和备受推崇的博士和医学博士项目中吸引博士前候选人；以及来自PSOM和CHOP竞争激烈的血液学奖学金项目的博士后申请者，以及来自全国领先实验室的博士后申请者。研究指导由24位科学和经验丰富的培训师提供，他们的研究兴趣几乎涵盖了造血的所有领域。该计划的学术内容包括课程作业、研讨会、实验室工作、指导和职业咨询、演讲、手稿和拨款写作等综合课程，这些内容有效地结合起来，培养造血科学基础方面的新研究者。学员将根据书面和口头报告、个性化发展计划以及与PI/PD以及研究和项目导师的状态会议进行评估。这种教学方法的成功体现在被任命者的数量上，他们已经在学术界和工业界取得了领导地位，在项目毕业后获得了成功的资助，并对生物医学文献做出了重大贡献。2011年，在前任PI/PD去世后，造血项目的领导层发生了变化，促使对项目目标和政策进行了全面审查，这些目标和政策加强了培训经验，并有望影响未来的结果评估。该审查还发现，宾夕法尼亚大学有大量高素质的博士预科生，他们的职业兴趣是造血；因此，本申请需要两个额外的职位，专门为这些联合学位的学生，以鼓励和支持他们在这一领域的职业发展。总而言之，造血项目是精心设计的，以培养造血基础知识的个人，目标是在这一重要且不断发展的人类生物学领域发展研究领导地位。

DESCRIPTION (provided by applicant): This application requests a renewal of the Hematopoiesis Training Grant, which was founded in 1999 to address the shortage in training opportunities for scientists and physician-scientists with career interests in hematopoiesis and hematopoietic stem cell biology; and to provide a core scientific leadership in this growing discipline for the next generation. The Hematopoiesis Program is a multi-disciplinary, cross-departmental training program that capitalizes on the extensive resources of the University of Pennsylvania School of Medicine (PSOM), The Children's Hospital of Pennsylvania (CHOP), and the Wistar Institute; selects appointees from pools of highly qualified trainees enrolled in their various pre- and post-doctoral programs; and encompasses faculty trainers with extensive funding, publication, and mentoring achievements. The Hematopoiesis Program has trained 17 post-doctoral and 5 pre-doctoral scientists with PhD, MD, or MD-PHD degrees, and currently accommodates an additional 3 post-doctoral and 3 pre-doctoral appointees. The Program draws pre-doctoral candidates from the large and highly regarded PhD and MD-PhD programs at the PSOM; and post-doctoral applicants from the competitive hematology fellowship programs at PSOM and CHOP, and from leading laboratories throughout the nation. Research mentorship is provided by 24 scientifically and experientially diverse trainers with research interests that encompass virtually all areas of hematopoiesis. The academic elements of the Program include an integrated curriculum of coursework, seminars, laboratory work, mentoring and career counseling, presentation, and manuscript and grant writing, which are effectively combined to train new investigators in the fundamentals of hematopoiesis science. Trainees are evaluated on the basis of written and oral presentations, Individualized Development Plans, and status conferences with the PI/PD and both research and Program mentors. The success of this instructional approach is indicated by the number of appointees who have progressed to leadership positions in academia and industry, have been successfully funded following Program graduation, and have made significant contributions to the biomedical literature. The Hematopoiesis Program underwent a change in leadership in 2011 following the death of its previous PI/PD, prompting a comprehensive review of programmatic goals and policy that have strengthened the training experience and are expected to impact future outcomes evaluation. The review also identified a large pool of highly qualified pre-doctoral MD-PhD students at Penn with career interests in hematopoiesis; consequently, this application requests two additional positions that are dedicated to these combined-degree students, to encourage and support their career progression in this area. In sum, the Hematopoiesis Program is carefully designed to train individuals in the fundamentals of hematopoiesis, with a goal of developing research leadership in this important and growing area of human biology.