Multi-Scale Electronic Human Brain Atlas

描述（由申请人提供）：在本申请中，我们建议开发一个多尺度，多模式的人类大脑图谱。该图谱将整合现代体内MRI、离体高分辨率MRI和连续组织学切片获得的不同空间分辨率的数据，覆盖1mm至小于1mm的尺度。健康受试者的全脑活体MRI将提供全局坐标系，所有高分辨率的数据都将注册到全局坐标系中，在同一坐标系下连接不同尺度的解剖信息。该图谱将作为一个IT基础设施，整合和传播来自不同来源、不同尺度（如临床MRI病例和组织学切片）的大量基于文本和图像的大脑解剖学知识。这些内容将在多尺度地图集中有机关联，为我们和用户提供的数据提供一个独特的组织、管理、呈现和使用环境。我们期望多尺度、多模式的大脑图谱将极大地提高我们组织、管理、呈现和利用大脑知识的能力。我们相信，我们拥有独特的资源和记录，可以为这一充满希望的努力做出贡献；我们推出了人类大脑的首批3D电子地图集之一。我们的脑地图集已被采纳为脑解剖学的标准研究工具之一，在过去发表了1000多篇论文。我们基于云的图像分析服务现在支持全球7000多名注册研究人员。在本提案中，我们将延续过去的努力，建立一个新的脑研究、教育和临床支持的信息学平台，目标如下：目的1：收集基于体内、离体MRI和组织学的多尺度、多模态人脑成像数据；目的2：构建多尺度地图集内容；目的3：构建多尺度地图集接口；目的4：测试基于云的地图集标签和坐标的信息链接

DESCRIPTION (provided by applicant): In this application, we propose to develop a multi-scale, multi-modal human brain atlas. The atlas will integrate data with different spatial resolution acquired by modern in vivo MRI, ex vivo high-resolution MRI, and serial histology sections, covering 1 mm scale to less than 1mm. The whole-brain in vivo MRI of healthy subjects will provide the global coordinate system, to which all higher-resolution data will be registered, connecting anatomical information with different scales under the same coordinate system. This atlas will serve as an IT infrastructure to integrate and disseminate a large amount of text and image-based anatomical knowledge of the brain from different sources at different scales such as clinical MRI cases and histology sections. These contents will be organically related in the multi-scale atlas, providing a unique environment to organize, manage, present, and use the data provided by us as well as by users. We expect the multi-scale, multi-modal brain atlas will hugely enhance our ability to organize, manage, present, and utilize our knowledge about the brain. We believe we have unique resources and track-records to contribute to this promising endeavor; we have introduced one of the first 3D electronic atlases of the human brain. Our brain atlases have been adopted as one of the standard research tools for brain anatomy, contributed to more than 1,000 publications in the past. Our cloud-based image analysis service now supports more than 7,000 registered researchers worldwide. In this proposal, we will extend our past effort and establish a novel informatics platform for brain research, education, and clinical support through the following aims; Aim 1: To collect multi-scale, multi-modal human brain imaging data based on in vivo and ex vivo MRI and histology Aim 2: To build multi-scale atlas contents Aim 3: To build the multi-scale atlas interface Aim 4: To test the cloud-based information link to the atlas labels and coordinates