2014 Mechanisms of Epilepsy and Neuronal Synchronization Gordon Research Conferen

描述（由申请人提供）：本提案要求NINDS支持将于2014年8月17日至22日在佛蒙特州雪山度假村举行的癫痫和神经元同步机制戈登研究会议。这是该系列的第四次会议。对于2014年版，组织者将会议重点放在与NINDS提出的“癫痫基准”直接相关的主题上。癫痫是一种常见的神经系统疾病，困扰着近300万美国人。这次会议将专门探讨尖端技术 研究促进对遗传性和获得性癫痫的潜在机制和新疗法的理解。鉴于癫痫研究几乎涵盖了生物组织的所有主要层次，从基因和离子通道到电路，干细胞，神经发育和行为，本次会议将包括解决这些独特类别的会议。这次戈登研究会议的主要目的是汇集遗传学家，分子生物学家，发育神经科学家，神经解剖学家，神经学家，电生理学家和计算神经科学家，研究与癫痫直接或间接相关的基本机制。发言者将被鼓励提出他们最新的，未发表的研究，跨越该领域的广度，并为未来的发现奠定了基础。本次会议的副主题是基因、突触和治疗学，将涵盖的主题包括：1）难治性癫痫类型的离子通道缺陷; 2）引入基因：癫痫突变的识别和表征; 3）中枢神经系统的发育和发育不良; 4）正常和癫痫大脑中的神经元微电路; 5）干细胞的拯救; 6）网络功能障碍和相关疾病的共病; 7）新的治疗策略：从基因治疗到药物干预; 8）抑制和兴奋障碍：对癫痫发生的影响。所有申请人将被鼓励提交摘要，大多数与会者将提出一个谈话或海报。对于每一个会议，一个发言者插槽将保留给初级研究员定义为博士后研究员或新的助理教授。这次会议在其相对较短的历史中，吸引了来自其职业生涯许多阶段的研究人员，并不断促进年轻研究人员和妇女的科学发展。我们将继续促进研究生和博士后研究员在这个GRC的出席和海报展示。

DESCRIPTION (provided by applicant): This proposal requests NINDS support for a Gordon Research Conference on Mechanisms of Epilepsy and Neuronal Synchronization to be held August 17-22, 2014, at Mount Snow Resort in Vermont. This is the 4th meeting in this series. For the 2014 edition, the organizers have focused the meeting on topics of direct relationship to the "epilepsy benchmarks" put forward by the NINDS. Epilepsy is a common neurological disorder afflicting nearly 3 million Americans. This meeting will specifically explore cutting edge research advancing the understanding of underlying mechanisms and novel therapies for both genetic and acquired epilepsies. Given that epilepsy research encompasses virtually all major levels of biological organization, from genes and ion channels to circuits, stem cells, neurodevelopment and behavior, this meeting will include sessions that address each of these unique categories. The major purpose of this Gordon Research Conference is to bring together geneticists, molecular biologists, developmental neuroscientists, neuroanatomists, neurologists, electrophysiologists, and computational neuroscientists working on basic mechanisms related either directly or indirectly to epilepsy. Speakers will be encouraged to present their latest, unpublished research that spans the breadth of the field and sets the stage for future discoveries. The sub-theme of the current conference is Genes, Synapses and Therapeutics, and the topics to be covered include: 1) Ion channel defects in intractable types of epilepsy; 2) Bring in the genes: Identification and characterization of epilepsy mutations; 3) Development and maldevelopment of the central nervous system; 4) Neuronal microcircuits in normal and epileptic brain; 5) Stem cells to the rescue; 6) Co-morbidities of network dysfunction and related disorders; 7) Novel therapeutic strategies: from gene therapy to drug intervention; and 8) Disorders of inhibition and excitation: implications for epileptogenesis. All applicants will be encouraged to submit an abstract and the majority of attendees will present a talk or poster. For each session, one speaker slot will be reserved for a junior investigator defined as a postdoctoral fellow or new Assistant Professor. This meeting has, in its relatively short history, attracted investigators from across many stages of their careers, and consistently promotes the scientific development of younger investigators and women. We will continue to promote attendance and poster presentations of graduate students and postdoctoral fellows at this GRC.