NICHD Cooperative Multicenter Neonatal Research Network

描述（由申请人提供）：全国儿童医院新生儿科和俄亥俄州州立大学提交本申请，以加入Eunice Kennedy Shriver NICHD合作多中心新生儿研究网络，以响应RFA-HD-10-003。我们机构的优势包括：1）一个真正的学术部门，由19名临床教员组成，具有出色的临床研究记录，2）2009年有2，197名新生儿重症监护室住院患者，其中615名胎龄<= 32周，539名出生体重<1500克，3）与母胎医学的充满活力的合作关系以及我们的机构与NICHD MFMU之间长期而成功的关系，4）位于研究所的围产期研究动态中心，其中包括一个充满活力的临床研究企业俄亥俄州围产期研究网络，以及5）预防早产及其并发症的强大机构承诺。事实上，预防早产是NCH战略计划的重点。所有这些优势将大大有助于NICHD NRN研究。此外，我们的人口非常接受和同意参与与早产有关的临床研究。我们的临床能力是深远的，基本上包括每一个早产儿提供的服务。我们有一个新生儿随访计划，已被证明特别适合临床方案中受试者的随访。我们的概念申请题为“制定早产儿个性化医学方法”，汇集了胚胎学，遗传学，数学医学和生物统计学，以制定针对早产儿并发症的个性化医学方法。这个概念应用程序展示了我们在获取，存储和分析大量数据集方面的专业知识。这种专门知识对于NICHD NRN可能在未来几年进行的任何“组学”类型的研究都是必要的。我们的资产，丰富的临床材料，优秀的机构支持，MFM和儿科学之间的特殊合议，专门的儿科研究所的资源，以及优秀的学术儿科学家使NCH/OSU成为NICHD NRN的理想场所。

DESCRIPTION (provided by applicant): The Division of Neonatology of Nationwide Children's Hospital and The Ohio State University submits this application to join the Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal Research Network in response to RFA-HD-10-003. Strengths of our Institution include: 1) a truly academic Division that consists of 19 clinical faculty members with an exceptional record of clinical research, 2) a large and medically diverse population available for clinical studies with 2,197 NICU admissions in 2009 of which 615 were <= 32 weeks gestational age and 539 were <1500 grams birthweight, 3) a vibrant collaborative relationship with maternal-fetal medicine and a long and successful relationship between our institution and the NICHD MFMU, 4) a dynamic Center for Perinatal Research housed in the Research Institute, which includes a vigorous clinical research enterprise the Ohio Perinatal Research Network, and 5) a robust Institutional commitment to preventing prematurity and its complications. Indeed, preventing prematurity is the focus of NCH's strategic plan. All of these strengths will contribute greatly to NICHD NRN studies. Furthermore, our population is very receptive and agreeable to participation in clinical studies related to preterm birth. Our clinical capabilities are far reaching and include essentially every service offered to preterm neonates. We have a neonatal follow-up program that has proven to be particularly well suited to follow-up of subjects in clinical protocols. Our concept application entitled, "Developing a Personalized Medicine Approach to Preterm Infants", brings together neonatology, genetics, mathematical medicine, and biostatistics to develop a personalized medicine approach to the complications of prematurity. This concept application demonstrates our expertise in acquiring, storing and analyzing vast data sets. This expertise will be necessary for any "omic" types of studies that the NICHD NRN may undertake in the years to come. Our assets, abundant clinical material, outstanding institutional support, exceptional collegiality between MFM and neonatology, the resources of a dedicated pediatric research institute, and outstanding academic neonatologists make NCH/OSU an ideal site for the NICHD NRN.