Molecular Signatures of LUTS-associated BPH

描述(由申请者提供)：宏伟的愿景是在精准医学概念的基础上，在斯坦福大学建立一个良性泌尿外科跨学科研究中心。长期目标是通过对良性前列腺增生症(BPH)的创新和精确的分子理解来减轻下尿路症状(LUTS)的负担。该中心将由一个跨学科团队领导，该团队拥有泌尿学、病理学、基因组学、分子和细胞生物学、微生物学和细胞培养建模方面的专业知识。科学研究项目致力于该中心的研究目标，目的是生成一个新的BPH分子分类，并从功能上检查每个亚类中的候选驱动因素。这些目标将涉及基于序列的转录图谱和使用条件重编程细胞(CRC)技术开发新的BPH细胞培养模型。这些发现将支持BPH和LUTS的后续翻译研究，并为挖掘数据和BPH细胞模型提供关键资源。行政核心将监督和协调中心的活动，教育丰富计划将通过实习生研讨会、研讨会和研究经验激励未来的良性泌尿外科研究人员。总而言之，该中心的跨学科研究和教育丰富活动有望为通过精确医学减轻LUTS的负担做出重大而持久的贡献。

DESCRIPTION (provided by applicant): The broad vision is to develop an Interdisciplinary Research Center in Benign Urology at Stanford University based on the concepts of precision medicine. The long-term goal is to reduce the burden of lower urinary tract symptoms (LUTS) through innovative and precise molecular understanding of benign prostatic hyperplasia (BPH). The center will be led by an interdisciplinary team with expertise in urology, pathology, genomics, molecular & cell biology, microbiology, and cell-culture modeling. The Scientific Research Project addresses the research goals of the Center with aims that will generate a new molecular classification of BPH and functionally examine candidate drivers within each subclass. These aims will involve sequence-based transcriptional profiling and the development of novel BPH cell culture models using conditionally reprogrammed cell (CRC) technology. Findings will support follow-on translational studies of BPH and LUTS, and provide key resources in minable data and BPH cell models. An Administrative Core will oversee and coordinate Center activities, and an Educational Enrichment Program will motivate future benign-urology researchers through trainee seminars, workshops and research experiences. Together, the Center's interdisciplinary research and educational enrichment activities are expected to make a significant and lasting contribution to reducing the burden LUTS through precision medicine.