L-amino acid sensing by the extracellular calcium-sensing receptor: molecular, cellular and in vivo studies

Conigrave博士和他的同事最近的工作首次证明，蛋白质和钙代谢通过广泛分布的钙感应受体在分子水平上联系在一起。该项目旨在通过测试人体蛋白质的组成成分L氨基酸是否对调节人体钙水平的激素的分泌和血液水平施加受体依赖的控制，来证明这一发现的生理学意义。它将通过确定氨基酸是否对骨形成细胞的增殖和尿钙排泄施加受体依赖的控制来进一步检验这一假说。

Recent work by Dr Conigrave and colleagues demonstrates for the first time that protein and calcium metabolism are linked at the molecular level by the widely distributed calcium-sensing receptor. The project will aim to demonstrate the physiological significance of this finding by testing whether L-amino acids, the building blocks of body protein, exert receptor-dependent control over the secretion and blood levels of hormones that regulate body calcium levels. It will further test the hypothesis by determining whether amino acids exert receptor-dependent control over the proliferation of bone forming cells and urinary excretion of calcium.