Clinical Core

研究核心：临床核心摘要 临床核心的基础是ANCA肾炎(GN)的互动登记 患者可以进行长期的患者随访和生物样本采集。我们的 初始队列现在包括868名患者，从诊断开始一直到现在都在进行前瞻性跟踪 他们的病程和生命，直到死亡。我们的临床核心有一个非常成功的记录 通过超过登记目标和患者保留来体现保留和跟踪 目前资助的项目。利用临床数据组织协议访问和系列样本 收集允许协调以患者为基础的科学研究，否则不会 有可能。丰富多样的患者表现以及对疾病和治疗的反应使这一点成为可能 在ANCA GN的演示过程中，初始队列提供重要的样本。《核心》 确保项目1、2和4以及项目1、2和4有足够的样本规模和适当的招聘 为所有项目提供统计规划、分析和解释。核心拥有 成功支持此计划项目，并参与了多份相关出版物 具体的目标和具体的项目。核心也获得了杰出的声誉， 指导和协作研究。我们共享了未识别的数据，以最大限度地提高 队列的研究潜力，并已收集新数据或从我们的 本计划项目以外研究的队列。核心部门的努力支持拟议的 项目，我们的合作努力带来了创新的研究，不断地带来 新的想法，新的研究人员和对ANCA研究界的整体热情。

Research Core: Clinical Core Abstract The foundation of the clinical core is an interactive registry of ANCA glomerulonephritis (GN) patients which allows long-term patient follow-up and biological sample collection. Our inception cohort now includes 868 patients followed prospectively from diagnosis throughout their disease course and life until death. Our clinical core has an extremely successful record of retention and follow up manifested by exceeding enrollment goals and patient retention for the currently funded Projects. Organization of protocol visits and serial samples with clinical data collection allows orchestration of patient based scientific research that would otherwise not be possible. Rich variety in patient presentation and response to disease and therapy allows this inception cohort to supply vital samples across the presentations of ANCA GN. The Core ensures adequate sample sizes and appropriate recruitment for projects 1, 2 and 4 as well as providing statistical programming, analyses and interpretation for all projects. The Core has successfully supported this Program Project with participation in numerous publications related to specific aims and specific projects. The Core has also gained an outstanding reputation for mentoring and collaborative research. We have shared de-identified data to maximize the research potential of the cohort and have collected new data or recruited patients from our cohort for studies outside of this Program Project. The efforts of the Core sustain the proposed projects, and our collaborative efforts have led to innovative research that continually brings new ideas, new investigators and overall enthusiasm to the ANCA research community.