Comp C-Urological Managment of Newborns with Spina Bifida

描述（由申请人提供）：脊柱裂是一种主要的先天性脊髓和相关椎骨异常。它的发病率约为每1000名新生儿1例，目前在美国的临床患病率超过70，000人。它是导致多器官系统严重残疾的最常见的出生缺陷。脊髓损伤对神经系统、骨科和泌尿系统有许多有害影响。脊柱裂患儿的泌尿外科评估始于出生时。尽管普遍同意的重要性，早期泌尿外科管理的婴儿，一些年来一直有一个重大的争议，以何种形式的管理是最适当的。本研究的目的是，利用一个定义明确的最佳实践协议，进行一项多机构研究， 年，以确定最适当的形式泌尿管理婴儿出生脊柱裂。本研究的目的还在于评估研究期结束时的多种功能结局指标，包括肾功能和膀胱动力学的具体测量。

DESCRIPTION (provided by applicant): Spina bifida is a major congenital anomaly of the spinal cord and the associated vertebrae. It has an incidence of roughly 1 per 1000 births and a current clinical prevalence of greater than 70,000 people in the United States. It is the most common birth defect that results in severe disability of multiple organ systems. The spinal cord lesion has numerous deleterious effects on the neurologic, orthopedic and urologic systems. Urological evaluation of infants with spina bifida begins at birth. Despite universal agreement on the importance of early urological management of the infant, for some years there has been a major controversy as to what form of management is most appropriate. The aim of this research is, utilizing a well defined best practices protocol, to conduct a multi-institutional study over 5 years to determine the most appropriate form of urologic management in infants born with spina bifida. The purpose of the research is also to assess numerous functional outcome measures at the end of the study period including specific measurements of renal function and bladder dynamics.