Impact of Traumatic Brain Injury on Brain Aging and Dementia

项目摘要 拟议的试点研究申请，题为创伤性脑损伤对脑老化的影响， 和痴呆症旨在确定创伤性脑损伤（TBI）史是否会增加风险 对于以后的生活神经退行性衰退，在心脏病研究第1代（Gen 1; n=5209）队列。该项目利用现有的健康，生活方式，生物标志物，遗传，认知 和神经影像学数据来研究TBI及其后果， 基于社区的样本，已被前瞻性地跟踪了近40年的痴呆症。 对于这个试点项目，我们计划确定中度至重度TBI， 记录（vTBI）并记录vTBI的患病率。然后我们将确定历史是否 vTBI与加速认知衰退和痴呆的风险增加有关， 尤其是老年痴呆症我们还将检查TBI指标是否与 脑萎缩和白色物质改变。此外，我们将讨论以下问题： vTBI病史是否与情绪和日常生活的短期和长期变化相关 功能最后，我们还将寻求确定代谢和炎症生物标志物 与vTBI相关，以及特定的遗传标记是否改变了vTBI与 TBI和健康结果。这项试点研究的结果将为更大规模的 规模研究主要的长期目标是确定TBI的后果是否 与痴呆症和其他健康相关结果的风险增加有关， 基于社区的样本这项研究的结果将有助于确定重要的长期- TBI对公共卫生的影响。

Project Summary The proposed pilot study application, entitled Impact of Traumatic Brain Injury on Brain Aging and Dementia seeks to determine whether history of traumatic brain injury (TBI) increases risk for later life neurodegenerative decline in the Framingham Heart Study Generation 1 (Gen 1; n=5209) cohort. This project leverages available health, lifestyle, biomarker, genetic, cognitive and neuroimaging data to study TBI and its consequences in a comprehensively characterized community-based sample that has been followed prospectively for dementia for nearly 40 years. For this pilot project, we plan to identify moderate to severe TBI that is validated by medical records (vTBI) and document the prevalence of vTBI. We will then determine whether history of vTBI is associated with increased risk for accelerated cognitive decline and dementia, particularly Alzheimer's Disease. We will also examine whether the TBI metrics are associated with greater brain atrophy and changes in white matter. Further, we will address the question of whether history of vTBI is associated with short- and long-term changes in mood and daily functioning. Finally, we will also seek to identify metabolic and inflammatory biomarkers associated with vTBI and whether specific genetic markers modify the relationships between TBI and health outcomes. The results from this pilot study will lay the foundation for a larger scale study. The primary long-term objective is to determine whether the consequences of TBI are related to increased risk for dementia and other health related outcomes within a community-based sample. Results from this research will help determine the significant long- term public health implications of TBI.