Center for Psychiatric Neuroscience

说明(申请人提供)：抑郁症是造成全球疾病负担的第三大因素；酒精和非法药物使用是造成这一负担的十大因素之一(世界卫生组织，《全球疾病负担：2004年更新》)。在Cobre资助的十年中，密西西比大学医学中心(UMMC)的精神神经科学中心(CPN)开发了尖端核心设施，并将重点扩展到抑郁症和酒精依赖领域。创新和多学科中心的研究人员在神经元和胶质细胞、脑血管、衰老、性别、转录因子、5-羟色胺和谷氨酸在抑郁症和酒精中毒中的作用方面进行了开创性的观察，许多人获得了独立的资金。我们在第三阶段的任务是通过促进指导，加强研究核心，继续建设精神疾病和精神活性物质使用障碍的病理生理学的基础研究，从而增加密西西比州国立卫生研究院的资金。实现这一使命的具体目标是：1)提供支持，以维护和扩大对支持整个机构和州的基础研究至关重要的最先进的研究核心；2)促进支持创新试点研究的协作和多学科指导环境；3)发展一个由研究人员发起的研究资助和合作计划项目支持的自给自足的生物医学研究卓越中心。我们的协同研究核心可在整个机构范围内获得，并可供其他Cobre和INBRE研究人员使用，将允许沿着使用成像核心和分子和基因组学核心来量化死后大脑核心组织中特定疾病的病理并在动物行为核心中对此类病理进行建模的指导项目的发展，以开发精神病理学的表型模型，并探索抑郁症和精神活性物质使用障碍(包括酒精依赖)的新治疗方法。最先进的研究核心将支持有指导的基础研究，为这些全球性的精神健康挑战寻找新的预防和治疗策略。

DESCRIPTION (provided by applicant): Depression is the 3rd leading contributor to the global burden of disease; alcohol and illicit drug use are among the top ten contributors to that burden (World Health Organization The Global Burden of Disease: 2004 Update). In ten years of COBRE funding, the Center for Psychiatric Neuroscience (CPN) at The University of Mississippi Medical Center (UMMC) developed cutting-edge core facilities and expanded its focus to the areas of depression and alcohol dependence. Innovative and muitidisciplinary Center investigators have collaborated in ground breaking observations on the roles of neurons and glia, cerebral vasculature, aging, gender, transcription factors, serotonin and glutamate in depression and alcoholism and many have secured independent funding. Our mission in Phase III is to continue building basic research in the pathophysiology of mental illnesses and psychoactive substance use disorders by promoting mentoring, strengthening research cores and, thereby, to increase NIH funding in Mississippi. Specific Aims toward reaching this mission are to: 1) provide support to maintain and expand state-of-the-art research cores that are essential to support basic research across the institution and the state, 2) promote a collaborative and muitidisciplinary mentoring environment that supports innovative pilot research, and 3) develop a self-sustaining center of biomedical research excellence supported by investigator-initiated research grants and collaborative program projects. Our synergistic research cores, available across the institution and state-wide to other COBRE and INBRE investigators, will permit the development of mentored projects along a trajectory of using the Imaging Core and the Molecular and Genomics Core to quantify disease-specific pathology in tissues from the Postmortem Brain Core and modeling such pathology in the Animal Behavior Core to develop phenotypic models of psychopathology and explore novel treatments for depression and psychoactive substance use disorders, including alcohol dependence. State-of-the-art research cores will support mentored basic research in search of new strategies of prevention and treatment for these global challenges to mental health.