How Can Precision Medicine be Applied to Temporomandibular Disorders and its Comorbidities?

项目总结 TMJ协会第八次科学会议，精准医学如何应用于 颞下颌关节紊乱病及其合并症？将于2016年9月11日至13日在以下地点举行 位于马里兰州贝塞斯达的美国实验生物学学会联合会会议中心。这个 需要召开这次会议是由几个关键问题推动的：第一，估计有3600万人受到影响 美国的颞下颌关节紊乱症(TMD)，大多数是育龄妇女，患有 随之而来的身体、心理和经济负担。第二，继续缺乏 对这些疾病的病因、诊断、并存和治疗有科学的认识。第三, TMD代表一种慢性疼痛状况，它是一系列普遍存在的疼痛状况之一 经常同时发生，并主要影响妇女。2016年会议的重点是如何通过 精准医学可以为TMD的治疗和如此多的患者并发疼痛情况提供信息 经验。目前的诊断和治疗方法不能反映科学的现状，在 满足有症状患者的需求。精确医学技术在战区导弹防御系统中的应用 合并症将使提供者能够更准确地将TMD患者分成不同的亚组 具体的诊断标准，并导致量身定做，更成功的治疗，以减轻他们的痛苦和痛苦。 演讲和讨论将集中在获得精确的分子和表型的挑战上 来自数千名患者的测量，重复和有效地。解决以下挑战的方法 分析和集成来自多种模式的大数据集，例如临床测量、成像数据、 将讨论DNA序列变异和表观遗传学特征。这次会议将使关键的科学工作者 领导人、NIH代表和患者权益倡导者，并将制定建议，以推进 这块地。会议的具体目标是： 1.召集科学家共同探讨如何应用精准医学来推进诊断和治疗 治疗TMD患者亚群的独特病理和合并疼痛情况。 2.评估在精准医学领域可以开展哪些类型的研究，以及如何汇总“N- OF-1试验“可以提供关于如何改善这些疼痛患者的治疗的信息。 3.确定哪些生理和临床测试(遗传、神经、微生物体等)可以做到最好 描述TMD患者的亚群，使其能够进行更有选择性和更有效的治疗。 4.邀请和介绍下一代年轻研究人员进入TMD和共病疼痛领域 以及它们所代表的基础和临床研究挑战/机遇。 5.为科学界和美国国立卫生研究院提出建议，这将增进我们对 如何将精准医学中的应用应用于TMD和慢性疼痛的共病。

PROJECT SUMMARY The Eighth Scientific Meeting of The TMJ Association, How Can Precision Medicine be applied to Temporomandibular Disorders and its Comorbidities?, is scheduled to be held on September 11-13, 2016 at the Federation of American Societies for Experimental Biology Conference Center in Bethesda, Maryland. The need for this meeting is driven by several critical issues: First, there are an estimated 36 million people affected by temporomandibular disorders (TMD) in the US, the majority being women in their childbearing years with consequential physical, psychological and financial burdens. Second, there continues to be a dearth of scientific understanding of the etiology of these conditions, their diagnosis, comorbidities and treatment. Third, TMD represents a chronic pain condition, which is one among a cluster of prevalent pain conditions that frequently co-occur and predominantly affect women. The 2016 meeting is focused on how methods of Precision Medicine can inform the treatment of TMD and the comorbid pain conditions so many patients experience. Current diagnostics and treatments do not reflect the current state of the science and fall short in meeting the needs of symptomatic patients. The application of Precision Medicine technology to TMD and its comorbidities will enable providers to more accurately classify TMD patients into subgroups according to specific diagnostic criteria and lead to tailored, more successful treatments to relieve their pain and suffering. Presentations and discussions will focus on the challenges of obtaining precise molecular and phenotypic measurements from thousands of patients, repeatedly and efficiently. Challenges addressing methods to analyze and integrate large data sets from multiple modalities such as clinical measurements, imaging data, DNA sequence variants, and epigenetic profiles will be addressed. The meeting will engage key scientific leaders, NIH representatives and patient advocates and will develop recommendations to advance research in this field. The Specific Aims of the conference are to: 1. Convene scientists to explore how “precision medicine” can be applied to advance the diagnostics and treatments of the unique pathologies of subsets of TMD patients and comorbid pain conditions. 2. To assess what kinds of studies could be mounted in precision medicine and how aggregated results of “N- of-1 trials” can provide information on how to improve treatment of patients with these pain conditions. 3. Determine which physiological and clinical tests (genetic, neurological, micobiomic, etc.) can best characterize subsets of TMD patients enabling more selective—and more effective—treatments. 4. Invite and introduce the next generation of young investigators to the field of TMD and comorbid pain conditions and to the basic and clinical research challenges/opportunities they represent. 5. Develop recommendations for the scientific community and NIH which will advance our understanding of how applications in precision medicine would be applied to TMD and comorbid chronic pain conditions.