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Genetics and Epigenetics - Temporomandibular Disorders and Related Overlapping Co

遗传学和表观遗传学 - 颞下颌疾病和相关重叠疾病

基本信息

批准号：
8785556
负责人：
Allen W Cowley
金额：
$ 3万
依托单位：
TMJ ASSOCIATION
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-01 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8785556
关键词：
Address Affect Am 80 American Behavioral Biological Biology Cell physiology Chronic Chronic Disease Chronic Fatigue Syndrome Comorbidity Complex Computing Methodologies Cytosine DNA Methylation Data Development Disease Disease Pathway Environmental Risk Factor Epigenetic Process Etiology Family Fibromyalgia Functional disorder Gene Expression Profile Gene Expression Regulation Genes Genetic Genetic Polymorphism Genetic Transcription Genome Genomics Goals Interstitial Cystitis Link Maryland Messenger RNA Modality Modeling Molecular Pain Pain Nature Pathology Pathway interactions Patient advocacy Patients Persistent pain Recommendation Regulation Regulator Genes Research Resolution Schedule Scientist Site Societies Solid Symptoms Technology Temporomandibular Joint Temporomandibular Joint Disorders Tissues United States National Institutes of Health Variant Vulvodynia Woman base bisulfite child bearing chronic pain chronic widespread pain computerized tools cost effective therapy endometriosis environmental stressor epigenome experience genetic association genome sequencing meetings next generation novel novel strategies psychologic public health relevance sex symposium therapeutic target

项目摘要

DESCRIPTION (provided by applicant): The Seventh Scientific Meeting of The TMJ Association, "Genetic and Epigenetic Basis of Temporomandibular Disorders and Related Chronic Overlapping Conditions," is scheduled to be held on September 7-9, 2014 at the Federation of American Societies for Experimental Biology Conference Center in Bethesda, Maryland. The need for this meeting is driven by two critical issues. First, there are an estimated 36 million people affected by Temporomandibular Disorders (TMJD) in the U.S., the majority being women in their childbearing years with consequential physical, psychological and financial burdens. Second, there continues to be a dearth of scientific understanding of the etiology and pathophysiology of these conditions, their comorbidities and treatment. To stimulate research in this field, The TMJ Association has organized six scientific meetings beginning in the year 2000 which have convened interdisciplinary groups of scientists to characterize and address the complex symptoms and frequently found comorbid conditions in TMJD patients. The theme of the currently proposed meeting is built upon important new data from the OPPERA consortium and other studies which have now demonstrated that TMJD are a complex family of conditions influenced by genes, sex, environmental and behavioral triggers. These studies have provided a solid basis of understanding of the transcriptome and have identified polymorphisms associated with the vulnerability of patients to TMJD. Given recent technological advances in genomic sequencing it is now possible to undertake studies to explain how environmental factors and stressors affect the epigenome and the regulation of these genes. The proposed meeting will bring together experts to discuss and inform how the epigenome may expand our understanding of TMJD and the complex pathways that link the various associated comorbid conditions such as chronic pain. The meeting will engage key scientific leaders, NIH representatives and patient advocacy representatives who will develop recommendations to advance research in this field. The specific aims are to determine: 1. What is currently known about the underlying mechanisms of chronic generalized persistent pain? 2. What are meaningful research strategies that could help decipher the rules by which gene networks are regulated and help understand how such regulation affects cellular function leading to the overlapping chronic conditions associated with TMJD and persistent pain? 3. How can studies of the epigenome expand our understanding of TMJD and chronic persistent pain? 4. What computational methods and gene regulatory models will be required to advance these studies? 5. How to probe cellular pathways to determine the effects of epigenetic modulation using novel computational tools? 6. How can these novel approaches be used to identify targets and develop new treatment modalities for TMJD and comorbid chronic pain conditions?

描述（由申请人提供）：颞下颌关节协会第七次科学会议“颞下颌疾病和相关慢性重叠病症的遗传和表观遗传基础”定于 2014 年 9 月 7 日至 9 日在马里兰州贝塞斯达美国实验生物学会联合会会议中心举行。召开这次会议的必要性是由两个关键问题驱动的。首先，估计有在美国，有 3600 万人受到颞下颌关节紊乱病 (TMJD) 的影响，其中大多数是育龄妇女，她们承受着巨大的身体、心理和经济负担。其次，对这些病症的病因学和病理生理学、其合并症和治疗仍然缺乏科学认识。为了促进这一领域的研究，颞下颌关节协会从 2000 年开始组织了六次科学会议，召集了跨学科的科学家小组来描述和解决颞下颌关节病患者的复杂症状和常见的合并症。目前提议的会议的主题是建立在 OPPERA 联盟和其他研究的重要新数据的基础上的，这些数据现已证明，颞下颌关节紊乱病是一个受基因、性别、环境和行为触发因素影响的复杂疾病家族。这些研究为理解转录组提供了坚实的基础，并确定了与患者易患 TMJD 的易感性相关的多态性。鉴于基因组测序的最新技术进步，现在可以进行研究来解释环境因素和压力源如何影响表观基因组和这些基因的调节。拟议的会议将汇集专家，讨论并告知表观基因组如何扩大我们对颞下颌关节紊乱病以及连接慢性疼痛等各种相关合并症的复杂途径的理解。会议将邀请重要的科学领导者、美国国立卫生研究院 (NIH) 代表和患者权益代表参加，他们将提出建议以推进该领域的研究。具体目标是确定： 1. 目前对慢性全身持续性疼痛的潜在机制了解多少？ 2. 有哪些有意义的研究策略可以帮助破译基因网络的调节规则，并帮助了解这种调节如何影响细胞功能，从而导致与颞下颌关节紊乱病和持续性疼痛相关的慢性疾病重叠？ 3.表观基因组研究如何扩大我们对颞下颌关节紊乱病和慢性持续性疼痛的理解？ 4. 推进这些研究需要哪些计算方法和基因调控模型？ 5. 如何使用新型计算工具探测细胞通路以确定表观遗传调节的影响？ 6. 如何利用这些新方法来确定目标并开发针对 TMJD 和合并慢性疼痛病症的新治疗方式？