Genetics and Epigenetics - Temporomandibular Disorders and Related Overlapping Co

遗传学和表观遗传学 - 颞下颌疾病和相关重叠疾病

基本信息

批准号：
8785556
负责人：
Allen W Cowley
金额：
$ 3万
依托单位：
TMJ ASSOCIATION
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-01 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8785556
关键词：
Address Affect Am 80 American Behavioral Biological Biology Cell physiology Chronic Chronic Disease Chronic Fatigue Syndrome Comorbidity Complex Computing Methodologies Cytosine DNA Methylation Data Development Disease Disease Pathway Environmental Risk Factor Epigenetic Process Etiology Family Fibromyalgia Functional disorder Gene Expression Profile Gene Expression Regulation Genes Genetic Genetic Polymorphism Genetic Transcription Genome Genomics Goals Interstitial Cystitis Link Maryland Messenger RNA Modality Modeling Molecular Pain Pain Nature Pathology Pathway interactions Patient advocacy Patients Persistent pain Recommendation Regulation Regulator Genes Research Resolution Schedule Scientist Site Societies Solid Symptoms Technology Temporomandibular Joint Temporomandibular Joint Disorders Tissues United States National Institutes of Health Variant Vulvodynia Woman base bisulfite child bearing chronic pain chronic widespread pain computerized tools cost effective therapy endometriosis environmental stressor epigenome experience genetic association genome sequencing meetings next generation novel novel strategies psychologic public health relevance sex symposium therapeutic target

项目摘要

DESCRIPTION (provided by applicant): The Seventh Scientific Meeting of The TMJ Association, "Genetic and Epigenetic Basis of Temporomandibular Disorders and Related Chronic Overlapping Conditions," is scheduled to be held on September 7-9, 2014 at the Federation of American Societies for Experimental Biology Conference Center in Bethesda, Maryland. The need for this meeting is driven by two critical issues. First, there are an estimated 36 million people affected by Temporomandibular Disorders (TMJD) in the U.S., the majority being women in their childbearing years with consequential physical, psychological and financial burdens. Second, there continues to be a dearth of scientific understanding of the etiology and pathophysiology of these conditions, their comorbidities and treatment. To stimulate research in this field, The TMJ Association has organized six scientific meetings beginning in the year 2000 which have convened interdisciplinary groups of scientists to characterize and address the complex symptoms and frequently found comorbid conditions in TMJD patients. The theme of the currently proposed meeting is built upon important new data from the OPPERA consortium and other studies which have now demonstrated that TMJD are a complex family of conditions influenced by genes, sex, environmental and behavioral triggers. These studies have provided a solid basis of understanding of the transcriptome and have identified polymorphisms associated with the vulnerability of patients to TMJD. Given recent technological advances in genomic sequencing it is now possible to undertake studies to explain how environmental factors and stressors affect the epigenome and the regulation of these genes. The proposed meeting will bring together experts to discuss and inform how the epigenome may expand our understanding of TMJD and the complex pathways that link the various associated comorbid conditions such as chronic pain. The meeting will engage key scientific leaders, NIH representatives and patient advocacy representatives who will develop recommendations to advance research in this field. The specific aims are to determine: 1. What is currently known about the underlying mechanisms of chronic generalized persistent pain? 2. What are meaningful research strategies that could help decipher the rules by which gene networks are regulated and help understand how such regulation affects cellular function leading to the overlapping chronic conditions associated with TMJD and persistent pain? 3. How can studies of the epigenome expand our understanding of TMJD and chronic persistent pain? 4. What computational methods and gene regulatory models will be required to advance these studies? 5. How to probe cellular pathways to determine the effects of epigenetic modulation using novel computational tools? 6. How can these novel approaches be used to identify targets and develop new treatment modalities for TMJD and comorbid chronic pain conditions?

描述（由申请人提供）：TMJ协会的第七次科学会议，“颞下颌疾病的遗传和表观基础和相关的慢性重叠状况”，定于2014年9月7日至9日在马里兰州贝塞斯达实验生物学会议中心的美国社会联盟举行。这次会议的需求是由两个关键问题驱动的。首先，有一个估计的在美国受到颞下颌疾病（TMJD）影响的3600万人，大多数是育儿时期的妇女，其身体，心理和经济负担。其次，仍然缺乏对这些疾病的病因和病理生理学，它们的合并症和治疗的科学理解。为了刺激该领域的研究，TMJ协会从2000年开始组织了六次科学会议，这些会议召集了科学家的跨学科群体，以表征和解决复杂症状，并经常发现TMJD患者的合并症。当前提议的会议的主题是基于Oppera联盟的重要新数据，以及其他研究表明，TMJD是受基因，性别，环境和行为触发器影响的复杂疾病系列。这些研究提供了对转录组的理解的扎实基础，并确定了与患者对TMJD的脆弱性相关的多态性。鉴于基因组测序的最新技术进步，现在可以进行研究，以解释环境因素和压力源如何影响表观基因组和这些基因的调节。拟议的会议将召集专家讨论并告知表观基因组如何扩展我们对TMJD的理解以及将各种相关合并症（例如慢性疼痛）联系起来的复杂途径。这次会议将与主要的科学领袖，NIH代表和患者倡导代表联系，他们将开发建议在该领域进行研究的建议。具体目的是确定：1。当前对慢性持续持续性疼痛的基本机制有什么了解？ 2.哪些有意义的研究策略可以帮助破译基因网络受到调节的规则，并有助于理解这种调节如何影响细胞功能，从而导致与TMJD和持续性疼痛相关的重叠的慢性病？ 3.对表观基因组的研究如何扩展我们对TMJD和慢性持续疼痛的理解？ 4.推进这些研究需要哪些计算方法和基因调节模型？ 5。如何使用新型计算工具探测细胞途径来确定表观遗传调制的影响？ 6.如何使用这些新颖的方法来识别目标并为TMJD和合并症慢性疼痛条件开发新的治疗方式？