Comorbid Chronic Pain Conditions - Mechanisms, Diagnosis and Treatments

慢性疼痛共病 - 机制、诊断和治疗

• 批准号: 8203961
• 负责人: Allen W Cowley
• 金额: $ 5.75万
• 依托单位: TMJ ASSOCIATION
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2013-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8203961
• 关键词: Address; Advocate; Affect; Am 80; American; Area; Behavioral; Biology; Chronic Fatigue Syndrome; Chronic Headaches; Clinical; Communities; Complex; Diagnosis; Diagnostic; Discipline; Etiology; Family; Fibromyalgia; Fostering; Functional disorder; Funding; Gender; Genetic; Goals; Individual; Interstitial Cystitis; Irritable Bowel Syndrome; Jaw; Learning; Maryland; Mediating; Modality; Myalgia; Organ; Pain; Patient advocacy; Patients; Process; Recommendation; Research; Research Personnel; Resources; Schedule; Scientist; Societies; Symptoms; System; Temporomandibular Joint; Temporomandibular Joint Disorders; Training; Vulvodynia; Woman; advocacy organizations; base; child bearing; chronic pain; cost; effective therapy; endometriosis; experience; high risk; loved ones; meetings; psychologic; symposium; therapy development; wasting

DESCRIPTION (provided by applicant): The Sixth Scientific Meeting of The TMJ Association, "Comorbid Chronic Pain Conditions - Mechanisms, Diagnosis and Treatments", is scheduled to be held on June 5-7, 2010 at the Federation of American Societies for Experimental Biology Conference Center in Bethesda, Maryland. The need for this meeting and that of previous meetings has been based on two important factors. First, the number of people affected in the U.S. by temporomandibular disorders (TMD) is estimated to be approximately 36 million. The majority are women in their childbearing years. The physical, psychological and financial burden on these patients is compelling. Second, there continues to be a dearth of scientific understanding of the etiology of these conditions upon which to base diagnostics and develop safe and effective treatments. To stimulate research in this field, The TMJ Association has organized five scientific meetings beginning in the year 2000. These meetings have convened scientists in the temporomandibular disorders field and other disciplines to characterize and address the multiple symptoms and frequently found comorbid conditions in TMD patients. The theme of the sixth scientific meeting builds upon evidence from the five previous meetings demonstrating that TMD are a complex family of conditions influenced by genetics, gender, environmental and behavioral triggers mediating the vulnerability of patients to TMD and typically manifesting as more than jaw and muscle pain and jaw dysfunction. The sixth meeting will focus on the pathophysiological processes underlying the chronic pain conditions which co-exist with TMD and constitute comorbid chronic pain conditions (CCPC). They include: chronic fatigue syndrome, chronic headache, endometriosis, fibromyalgia, irritable bowel syndrome, interstitial cystitis, and vulvodynia. The meeting will engage key leaders and representatives from funding and patient advocacy organizations who will develop recommendations to advance research in this field. The specific aims of the meeting are to determine: 1. What is currently known about underlying mechanisms of CCPC; 2. What we need to know about CCPC (e.g., case definition, diagnostics); 3. What research areas are most promising to pursue (best approaches, resources); 4. How best to foster the development of treatment modalities for CCPC; 5. What approaches are necessary to encourage, train, and sustain a CCPC research community; and 6. What high-risk research areas have the potential to substantially advance our understanding of CCPC. PUBLIC HEALTH RELEVANCE: Up to 50 million Americans experience one or more of the following six conditions, also seen in many TMD patients - they are chronic fatigue syndrome, endometriosis, fibromyalgia, interstitial cystitis, temporomandibular disorders, and vulvodynia. The estimated cost of the six pain conditions alone is $80 billion, which, because of the lack of understanding their cause and the availability of effective treatments, is essentially wasted. This meeting will accelerate the scientific research which will contribute to the reduction of the suffering and financial burden these conditions place upon the patients, their loved ones and our nation as a whole.

描述（由申请人提供）： 颞下颌关节协会第六次科学会议“共病慢性疼痛状况 - 机制、诊断和治疗”定于 2010 年 6 月 5 日至 7 日在马里兰州贝塞斯达的美国实验生物学会联合会会议中心举行。本次会议和以往会议的必要性基于两个重要因素。首先，美国受颞下颌关节紊乱病 (TMD) 影响的人数估计约为 3600 万人。其中大多数是育龄妇女。这些患者的身体、心理和经济负担是巨大的。其次，对这些疾病的病因学仍然缺乏科学的认识，无法以此为基础进行诊断和开发安全有效的治疗方法。为了促进这一领域的研究，颞下颌关节协会从 2000 年开始组织了五次科学会议。这些会议召集了颞下颌疾病领域和其他学科的科学家来描述和解决 TMD 患者的多种症状和常见的合并症。第六次科学会议的主题建立在前五次会议的证据基础上，这些证据表明TMD是一系列复杂的疾病，受遗传、性别、环境和行为触发因素的影响，介导患者对TMD的脆弱性，通常不仅仅表现为下巴和肌肉疼痛以及下巴功能障碍。第六次会议将重点讨论与 TMD 共存并构成共病慢性疼痛状况 (CCPC) 的慢性疼痛状况的病理生理过程。它们包括：慢性疲劳综合征、慢性头痛、子宫内膜异位症、纤维肌痛、肠易激综合征、间质性膀胱炎和外阴痛。会议将邀请来自资助和患者倡导组织的主要领导人和代表，他们将提出建议以推进该领域的研究。会议的具体目标是确定： 1. 目前对 CCPC 底层机制的了解是什么； 2. 我们需要了解 CCPC 的哪些信息（例如病例定义、诊断）； 3. 最有希望开展哪些研究领域（最佳方法、资源）； 4. 如何最好地促进 CCPC 治疗方式的发展； 5. 需要采取哪些方法来鼓励、培训和维持 CCPC 研究社区； 6. 哪些高风险研究领域有可能大大增进我们对 CCPC 的理解。 公共卫生相关性：多达 5000 万美国人患有以下六种病症中的一种或多种，​​这些病症也见于许多 TMD 患者 - 它们是慢性疲劳综合征、子宫内膜异位症、纤维肌痛、间质性膀胱炎、颞下颌疾病和外阴痛。仅六种疼痛病症的估计费用就达 800 亿美元，由于缺乏对其原因的了解和有效治疗的可用性，这些费用基本上被浪费了。这次会议将加速科学研究，这将有助于减轻这些疾病给患者、他们的亲人和整个国家带来的痛苦和经济负担。