Comorbid Chronic Pain Conditions - Mechanisms, Diagnosis and Treatments

慢性疼痛共病 - 机制、诊断和治疗

• 批准号: 8203961
• 负责人: Allen W Cowley
• 金额: $ 5.75万
• 依托单位: TMJ ASSOCIATION
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2013-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8203961
• 关键词: Address; Advocate; Affect; Am 80; American; Area; Behavioral; Biology; Chronic Fatigue Syndrome; Chronic Headaches; Clinical; Communities; Complex; Diagnosis; Diagnostic; Discipline; Etiology; Family; Fibromyalgia; Fostering; Functional disorder; Funding; Gender; Genetic; Goals; Individual; Interstitial Cystitis; Irritable Bowel Syndrome; Jaw; Learning; Maryland; Mediating; Modality; Myalgia; Organ; Pain; Patient advocacy; Patients; Process; Recommendation; Research; Research Personnel; Resources; Schedule; Scientist; Societies; Symptoms; System; Temporomandibular Joint; Temporomandibular Joint Disorders; Training; Vulvodynia; Woman; advocacy organizations; base; child bearing; chronic pain; cost; effective therapy; endometriosis; experience; high risk; loved ones; meetings; psychologic; symposium; therapy development; wasting

DESCRIPTION (provided by applicant): The Sixth Scientific Meeting of The TMJ Association, "Comorbid Chronic Pain Conditions - Mechanisms, Diagnosis and Treatments", is scheduled to be held on June 5-7, 2010 at the Federation of American Societies for Experimental Biology Conference Center in Bethesda, Maryland. The need for this meeting and that of previous meetings has been based on two important factors. First, the number of people affected in the U.S. by temporomandibular disorders (TMD) is estimated to be approximately 36 million. The majority are women in their childbearing years. The physical, psychological and financial burden on these patients is compelling. Second, there continues to be a dearth of scientific understanding of the etiology of these conditions upon which to base diagnostics and develop safe and effective treatments. To stimulate research in this field, The TMJ Association has organized five scientific meetings beginning in the year 2000. These meetings have convened scientists in the temporomandibular disorders field and other disciplines to characterize and address the multiple symptoms and frequently found comorbid conditions in TMD patients. The theme of the sixth scientific meeting builds upon evidence from the five previous meetings demonstrating that TMD are a complex family of conditions influenced by genetics, gender, environmental and behavioral triggers mediating the vulnerability of patients to TMD and typically manifesting as more than jaw and muscle pain and jaw dysfunction. The sixth meeting will focus on the pathophysiological processes underlying the chronic pain conditions which co-exist with TMD and constitute comorbid chronic pain conditions (CCPC). They include: chronic fatigue syndrome, chronic headache, endometriosis, fibromyalgia, irritable bowel syndrome, interstitial cystitis, and vulvodynia. The meeting will engage key leaders and representatives from funding and patient advocacy organizations who will develop recommendations to advance research in this field. The specific aims of the meeting are to determine: 1. What is currently known about underlying mechanisms of CCPC; 2. What we need to know about CCPC (e.g., case definition, diagnostics); 3. What research areas are most promising to pursue (best approaches, resources); 4. How best to foster the development of treatment modalities for CCPC; 5. What approaches are necessary to encourage, train, and sustain a CCPC research community; and 6. What high-risk research areas have the potential to substantially advance our understanding of CCPC. PUBLIC HEALTH RELEVANCE: Up to 50 million Americans experience one or more of the following six conditions, also seen in many TMD patients - they are chronic fatigue syndrome, endometriosis, fibromyalgia, interstitial cystitis, temporomandibular disorders, and vulvodynia. The estimated cost of the six pain conditions alone is $80 billion, which, because of the lack of understanding their cause and the availability of effective treatments, is essentially wasted. This meeting will accelerate the scientific research which will contribute to the reduction of the suffering and financial burden these conditions place upon the patients, their loved ones and our nation as a whole.

描述（由申请人提供）：颞下颌关节协会第六次科学会议，“共病慢性疼痛状况-机制，诊断和治疗”，定于2010年6月5日至7日在马里兰州贝塞斯达的美国实验生物学学会联合会会议中心举行。召开本次会议和以往各次会议的必要性是基于两个重要因素。首先，据估计，美国患有颞下颌关节紊乱病（TMD）的人数约为3600万。大多数是育龄妇女。这些患者的身体、心理和经济负担是令人信服的。其次，仍然缺乏对这些疾病的病因学的科学认识，而诊断和开发安全有效的治疗方法正是基于这些认识。为了促进这一领域的研究，TMJ协会从2000年开始组织了五次科学会议。这些会议召集了颞下颌关节紊乱病领域和其他学科的科学家，以描述和解决TMD患者的多种症状和常见的合并症。第六次科学会议的主题建立在前五次会议的证据基础上，证明TMD是一个复杂的家族，受到遗传，性别，环境和行为触发因素的影响，介导患者对TMD的脆弱性，通常表现为下颌和肌肉疼痛以及下颌功能障碍。第六次会议将重点讨论慢性疼痛状况的病理生理过程，这些慢性疼痛状况与TMD共存，并构成共病慢性疼痛状况（CCPC）。它们包括：慢性疲劳综合征、慢性头痛、子宫内膜异位症、纤维肌痛、肠易激综合征、间质性膀胱炎和外阴痛。会议将邀请来自资助和患者倡导组织的主要领导人和代表参加，他们将提出建议，以推进这一领域的研究。会议的具体目标是确定：1。目前已知的CCPC的潜在机制; 2。我们需要了解的CCPC（例如，病例定义、诊断）; 3.哪些研究领域最有希望追求（最佳方法，资源）; 4。如何最好地促进CCPC治疗模式的发展; 5.什么方法是必要的，以鼓励，培训和维持CCPC研究社区;和6。哪些高风险研究领域有可能大大提高我们对CCPC的理解。 公共卫生关系：多达5000万美国人经历了以下六种疾病中的一种或多种，也见于许多TMD患者-它们是慢性疲劳综合征，子宫内膜异位症，纤维肌痛，间质性膀胱炎，颞下颌关节紊乱病和外阴痛。仅这六种疼痛症状的估计成本就达800亿美元，由于缺乏对其原因的了解和有效治疗的可用性，这些成本基本上被浪费了。这次会议将加速科学研究，这将有助于减少这些疾病给病人、他们的亲人和我们整个国家带来的痛苦和经济负担。