Diverse Drug Lead Compounds from Bacterial Symbionts in Philippine Mollusks

概述：菲律宾软体动物共生体ICBG （PMS-ICBG）利用菲律宾巨大的生物多样性来发现治疗细菌感染、寄生虫感染、疼痛和其他神经系统疾病和癌症的新药，所有这些都是菲律宾和美国的严重健康问题。菲律宾共和国拥有独特的生物多样性，人口密集，社会需求迫切，因此迫切需要保护，政府致力于教育和技术，以利用国家人力和自然资源实现可持续的未来。我们的重点是软体动物和它们的共生微生物；软体动物是海洋动物中最多样化的群体之一，与它们相关的细菌代表了尚未开发的化学多样性宝库。PMS- ICBG将利用我们对软体动物共生体与其宿主之间相互作用的日益加深的理解来发现最新颖和有用的分子。该项目将记录和描述菲律宾软体动物的生物多样性，并支持为保护菲律宾生物多样性提供基础的培训和基础设施。该项目由俄勒冈健康与科学大学海洋微生物学家Margo Haygood与菲律宾大学海洋天然产品化学家Gisela Concepcion联合领导；Baldomero Olivera，生物化学家和Eric Schmidt，天然产物化学家和生物化学家，他们都来自犹他大学，Gary Rosenberg，自然科学院的线虫学家，Drexel大学，Daniel Distel，海洋微生物学家，东北大学，Roberta O'Connor，塔夫茨医学中心的寄生虫学家。

DESCRIPTION (provided by applicant): Group Plan Summary: The Philippine Mollusk Symbiont ICBG (PMS-ICBG) harnesses the vast biodiversity of the Philippines to discover new drugs to treat bacterial infections, parasitic infections, pain and other neurological conditions and cancer, all of which are serious health problems in both the Philippines and the United States. The Republic of the Philippines represents a unique nexus of exceptional biodiversity, dense human population with pressing societal needs, consequent urgent need for conservation, and government commitment to education and technology to harness national human and natural resources for a sustainable future. Our focus is mollusks and their microbial symbionts; mollusks are one of the most diverse groups of marine animals, and their associated bacteria represent an unexplored trove of chemical diversity. The PMS- ICBG will use our increasing understanding of the interactions between mollusk symbionts and their hosts to discover the most novel and useful molecules. The project will document and describe Philippine mollusk biodiversity and support training and infrastructure that provide the foundation for conservation of Philippine biodiversity. The project is led by Margo Haygood, marine microbiologist, Oregon Health & Science University in association with Gisela Concepcion, marine natural products chemist, University of the Philippines, Diliman; Baldomero Olivera, biochemist and Eric Schmidt, natural products chemist and biochemist, both of University of Utah, Gary Rosenberg, malacologist, of the Academy of Natural Sciences, Drexel University, Daniel Distel, marine microbiologist, Northeastern University, and Roberta O'Connor, parasitologist, Tufts Medical Center.