Biospecimen Shared Resource

项目概述（见说明）：堪萨斯大学癌症中心（KUCC）建立了生物标本库活动，以协调组织和外周血样本的伦理收集、储存、注释和分发，以支持转化研究。这项全中心范围的活动由一个方案间内部咨询委员会（I AB）监督，最近由病理和检验医学系的Andrew K. Godwin监督。BSR有三个主要功能：1)识别参与者，管理知情同意，从选定人群中收集组织、血液和/或尿液样本，并获取个人和家庭癌症史、临床干预和生活方式因素的信息，以供研究使用；2)处理和保存通过研究者发起的研究获得的人类生物标本；3)提供组织标本的专家组织学技术规程和病理评价。经过专门培训的工作人员与病理学家、内科肿瘤学家、外科医生和其他医院工作人员合作，获得患者的同意，收集样本，并收集关于每个捐赠者和相应样本的全面临床信息。作为银行业务的一部分，BSR工作人员提供i)出色的诊断病理学支持；Ii)为研究使用患者和参与者的组织、血液和/或尿液制定全面的知情同意程序；Iii)专门的生物标本库，专门收集和分发标本以支持研究；Iv)来自每位参与者的临床记录和自述健康史的广泛支持数据，以及v)固定、石蜡处理、载玻片制备和常规染色、免疫组织化学支持、组织微阵列、图像分析和数字病理学。所有标本将被链接到由生物统计学和信息学共享资源支持的综合临床数据库。BSR目前有2000多例新鲜冷冻组织样本和2000多例血液样本，并有28000多例外科病理病例存档。2010年，BSR在四个项目中为16名（Q名同行评审资助）KUCC研究人员提供服务，包括分发382个新鲜和新鲜冷冻标本，666个活动单位以支持研究人员发起的研究，以及3105个组织技术服务单位。2010年，47.4%的BSR的使用是由同行评审资助的研究人员使用的。

PROJECT SUMMARY (See instructions): The University of Kansas Cancer Center (KUCC) has established biospecimen banking activities to coordinate the ethical collection, storage, annotation, and distribution of tissue and peripheral blood samples to support translational research. This center-wide activity is overseen by an inter-programmatic Internal Advisory Board (I AB), under the recent supervision of Andrew K. Godwin within the Department of Pathology and Laboratory Medicine. The BSR has three major functions: 1) identify participants, administer informed consent, collect tissue, blood, and/or urine samples from selected populations, and obtain information on personal and family histories of cancer, clinical intervention, and lifestyle factors for use in research; 2) process and house human biospecimens obtained through investigator-initiated studies; and 3) provide expert histology technical procedures and pathological evaluation of tissue samples. Working in collaboration with pathologists, medical oncologists, surgeons and other hospital personnel, specially trained staff obtain patient consent, collect samples and assemble comprehensive clinical information about each donor and the corresponding samples. As part of this banking the BSR staff provides i) outstanding diagnostic pathology support; ii) a comprehensive informed consent process for the use of tissue, blood, and/or urine from patients and participants for research; iii) a specialized biospecimen bank devoted to the collection and distribution of specimens to support research; iv) extensive supporting data from the clinical record and self-reported health history of each participant, and v) fixation, paraffin processing, slide preparation and routine staining, immunohistochemistry support, tissue microarray, image analysis and digital pathology. All specimens will be linked to comprehensive clinical databases supported by the Biostatistics and Informatics Shared Resource. The BSR currently houses over 2,000 cases with fresh-frozen tissue samples and over 2,000 cases with blood samples and has access to over 28,000 surgical pathology cases on file. In 2010 the BSR served 16 (Q peer-reviewed funded) KUCC investigators across the four programs, including distribution of 382 fresh and fresh-frozen specimens, 666 units of activity to support investigator-initiated studies, and 3,105 units of histotechnology services. 47.4% of the BSR's use in 2010 was by peer-reviewed funded investigators.