Imaging Core

成像共享资源核心的目的是通过提供和支持最先进的分子，功能和解剖成像来支持创新，多学科，转化研究。Imaging Core与UCLA Prostate SPORE研究人员密切合作，在其临床前和临床研究中实施和整合生物成像，以开发关键生物信息，促进前列腺癌的最佳检测，治疗和整体管理。Imaging Core提供多种临床前成像模式，包括microPET、microCT、光学（生物发光和荧光）和数字全身放射自显影。Imaging Core的临床部分提供了多参数MRI和MR Spectroscopy以及PET，用于生理和代谢的无创成像。此外，可以使用Artemis系统使用MRI/US配准进行靶向活检，或通过介入放射学进行CT引导活检。成像共享资源核心的作用是帮助研究人员进行实验设计，开发标准化和定量的图像解释方法，并解决技术障碍。Imaging Core还与Pathology Core紧密配合，用于目标组织采集。将这些活动集中在共享资源中，可确保SPORE项目的临床组成部分采用统一的方法和实施，这对于其成功至关重要。

The purpose of the Imaging Shared Resource Core is to support innovative, multidisciplinary, translational research through the provision and support of state-of-the-art molecular, functional, and anatomical imaging. The Imaging Core works closely with UCLA Prostate SPORE investigators to implement and integrate biological imaging in their preclinical and clinical studies in order to develop key biological information to foster the optimal detection, treatment, and overall management of prostate cancer. The Imaging Core provides access to a diverse spectrum of preclinical imaging modalities, including microPET, microCT, optical (bioluminescence and fluorescence) and digital whole body autoradiography. The clinical component of the Imaging Core provides access to multiparametric MRI and MR Spectroscopy.and PET for noninvasive imaging of physiology and metabolism. In addition, targeted biopsies can be conducted using MRI/US coregistration using the Artemis system, or through CT-guided biopsy by interventional radiology. The role of the Imaging Shared Resource Core is to aid investigators in experimental design, develop standardized and quantitative approaches to image interpretation, and to solve technical hurdles. The Imaging Core also works closely with the Pathology core for targeted tissue acquisition. Centralization of these activities in a Shared Resource ensures a uniform approach and implementation across the clinical components of the SPORE projects and is critical to their success.