Barriers in Translating Genomic Research into State Public Health Programs

描述（由申请人提供）：本修订后的指导研究科学家发展奖（K01）申请旨在支持威斯康星大学麦迪逊分校助理教授Laura Senier， MPH， PhD的职业生涯。Senier博士的目标是(1)在群体遗传学、公共政策分析和管理新兴基因技术的伦理框架方面获得额外的培训；(2)建立一个研究项目，探索将基因发现转化为公共卫生政策和项目的技术、政治和伦理障碍；(3)成为政治研究翻译的独立研究者。Senier博士将通过正式课程、指导合作和对国家公共卫生政策的实证研究相结合来实现这些目标。该研究计划检查了国家卫生机构公共卫生遗传学项目的现代化。具体目标是（目标1a）描述的概念模型，组织结构和融资解决方案，国家卫生机构正在使用现代化的公共卫生遗传学计划；（目标1b）探讨利益相关者对国家公共卫生遗传学计划的范围和适用性的意见和态度；（目标2a）通过比较案例研究，确定阻碍或促进将遗传学纳入公共卫生的关键因素；和（目标2b）解释了在不同的结构安排下公共卫生遗传学项目是如何变化的，并展示了利益相关者的意见是如何影响公共卫生遗传学项目的。针对研究部分审稿人提出的问题，修订后的申请澄清了抽样策略，并更彻底地解释了定性比较案例研究的分析方法。该研究将基于通过实地观察、深度访谈和对四个州（密歇根州、康涅狄格州、纽约州和犹他州）公共卫生遗传学活动的档案分析收集的原始数据。Senier博士已经招募了一个跨学科的导师委员会来指导她进行这些培训和研究活动。Pila Ossorio博士（法律与生命伦理学副教授）、Daniel Kleinman博士（社区与环境社会学教授兼主席）、Tom Oliver博士（人口健康科学教授）和D. Paul Moberg博士（人口健康研究所所长）将指导Senier博士进行这些工作。根据研究部分审稿人的建议，Nancy Cox博士（芝加哥大学）和Peter Conrad博士（布兰代斯大学）将加入指导委员会，提供额外的方法指导。总之，这个导师委员会在生物技术新出现的法律和伦理挑战方面具有专业知识；科学政策和卫生政策中的组织和政治障碍；在比较案例研究设计和项目评估研究方面创新研究方法。他们非常有资格，并完全致力于协助Senier博士进行多学科培训，研究和职业道路。

DESCRIPTION (provided by applicant): This revised application for a Mentored Research Scientist Development Award (K01) is designed to support the career of Laura Senier, MPH, PhD, an assistant professor at the University of Wisconsin-Madison. Dr. Senier's goals are (1) to obtain additional training in population genetics, public policy analysis, and ethical frameworks governing emerging genetic technologies; (2) to build a research program that explores technical, political, and ethical barriers in translating genetic discoveries to public health poliies and programs; and (3) to become an independent investigator in the politics of research translation. Dr. Senier will accomplish these goals through a combination of formal coursework, mentored collaboration, and empirical research on state public health policy. The research plan examines the modernization of public health genetics programs in state health agencies. The specific aims are to (Aim 1a) describe the conceptual models, organizational structures, and financing solutions that state health agencies are using to modernize public health genetics programs; (Aim 1b) explore the opinions and attitudes of stakeholders about the scope and suitability of state public health genetics programs; (Aim 2a) through a comparative case study, identify the critical elements that impede or promote integration of genetics into public health; and (Aim 2b) explain how public health genetics programs vary under different structural arrangements, and show how the opinions of stakeholders influence public health genetics programming. In response to questions from study section reviewers, this revised application clarifies the sampling strategy and explains the analytic method of the qualitative comparative case study more thoroughly. The research will be based on original data collected via field observation, in-depth interviews, and archival analysis of state public health genetics activities n four states (Michigan, Connecticut, New York, and Utah). Dr. Senier has recruited an interdisciplinary mentor committee to guide her in these training and research activities. Dr. Pila Ossorio (Associate Professor of Law and Bioethics), Dr. Daniel Kleinman (Professor and Chair of Community & Environmental Sociology), Dr. Tom Oliver (Professor of Population Health Sciences), and Dr. D. Paul Moberg, (Director, Population Health Institute) will guide Dr. Senier in these endeavors. At the suggestion of study section reviewers, Dr. Nancy Cox (University of Chicago) and Dr. Peter Conrad (Brandeis University) are joining the mentorship committee to provide additional methodological guidance. Together, this committee of mentors has expertise in the emerging legal and ethical challenges in biotechnology; organizational and political barriers in science policy and health policy; and innovative research methods in comparative case study design and program evaluation research. They are eminently qualified and fully committed to assisting Dr. Senier in her multidisciplinary training, research, and career path.