IGF::OT::IGF

青年冠状动脉风险发展研究是由美国国家心肺血液研究所于1985年建立的，目的是研究美国四个社区(亚利桑那州伯明翰、伊利诺伊州芝加哥、明尼阿波利斯明尼阿波利斯和加利福尼亚州奥克兰)青年时期心血管疾病风险的分布和演变(http://www.cardia.dopm.uab.edu/).最初的队列(n=5,115)的参与者人数在每个社区的年龄(18-24岁和25-30岁)、性别、种族(黑人和白人)和教育程度(高中以下和高中以上)的亚组中大致相同。在2015年7月1日至2016年6月30日的第八次考试中，参与者的年龄为48-60岁，这一时期危险因素和亚临床异常普遍存在，临床事件不断出现。CARDIA提供了解决亚临床和临床疾病的发展和进展方面的机会，这些方面在老年人群中是无法解决的。具体地说，CARDIA提供了对包括心力衰竭在内的大量白人和黑人成年人的早期心血管疾病进行表型的机会。此外，还可以更新心血管疾病的风险因素。根据先前检查中的危险因素数据，CARDIA有能力研究从成年期早期到中晚期危险因素的整个轨迹及其控制如何影响心功能障碍的发展和进展。

The Coronary Artery Risk Development in Young Adults (CARDIA) study was established in 1985 by the NationalHeart, Lung, and Blood Institute (NHLBI) to study the distribution and evolution of cardiovascular disease riskbeginning in young adulthood in four U.S. communities (Birmingham, AL; Chicago, IL; Minneapolis, MN; and Oakland,CA) (http://www.cardia.dopm.uab.edu/). The original cohort (n=5,115) was selected to have approximately the samenumber of participants in subgroups of age (18-24 and 25-30), sex, race (black and white), and education (high schoolor less and more than high school) within each community. At Year 30 the eighth examination (July 1, 2015- June30, 2016), participants will be 48-60 years old, a time when risk factors and subclinical abnormalities are prevalentand clinical events continue to emerge. CARDIA offers the opportunity to address aspects of the development andprogression of subclinical and clinical disease that cannot be addressed in older cohorts. Specifically, CARDIA offersthe opportunity to phenotype early cardiovascular disease, including heart failure in a large cohort of white andblack adults. In addition, risk factors for cardiovascular disease can be updated. With risk factor data from previousexaminations, CARDIA has the ability to study how the entire trajectory of early adulthood to mid-to-late middle-agerisk factors and their control affects development and progression of cardiac dysfunction.