Bioinformatics Core

生物信息学核心摘要 自2001年初以来，生物信息学核心一直是SD INBRE的关键组成部分。主要 生物信息学核心的目标是通过以下方式帮助所有参与机构的研究人员、教职员工和学生： 提供生物信息学教育机会；提供研究机会和支持；促进 跨学科和跨机构协作，提供基础设施支持，并支持在线图书馆 资源。具体目标包括：1)通过课程开发和 提供、讲习班和研讨会；2)支持研究和协作，协助研究人员管理 他们的研究数据，确定用于电子分析的工具，创建生物信息学工作流程，并利用网络- 支持协作小组的基础设施；3)安全、坚固和易于访问的网络基础设施； 以及4)SD Brin的在线图书馆资源。生物信息学是获取和分析蛋白质组学的基础， 基因组学和遗传学数据。因此，生物信息学核心提供的服务对 在整个网络中维持和发展教员的SD Brin生物医学研究工作，以及 满足生物医学研究多个领域对生物信息学技能日益增长的需求。对以下方面的影响 公共卫生是疾病进展和新药开发等领域研究的进步 治疗感染的药物。为实现这些目标，已经提出了几个行动步骤。创新活动 以及诸如创建适合远程学习的课程、创建生物信息学 学习门户和新型工作流管理系统的实施极大地促进了生物信息学的发展 对本科生和研究生以及教职员工进行教育，并支持共享数据、分析 工具和科学工作流程。与内布拉斯加大学奥马哈分校(和NE-INBRE)合作 生物信息学工作坊将被开发并提供给PUI本科生和导师。 生物信息学人员将协助SD Brin研究中心、教职员工和学生进行识别， 安装和执行适当的分析工具，以满足其数据采集、存储和分析 需要。高性能计算环境(在INBRE第一阶段创建)，大容量冗余 蛋白质组学和基因组学核心产生的数据的网络存储，以及研究数据服务器 将继续支持提供给公共政策研究所伙伴研究人员的援助。最后，SD Brin将继续提供 通过SD Brin支持的图书馆支持和访问大量科学期刊 数据库和资源访问。生物信息学支持将导致生物医学研究的加强 SD Brin教职员工和学生的能力和提高的工作效率广泛的网络。

Bioinformatics Core Summary The Bioinformatics Core has been a key component of SD INBRE since the beginning in 2001.The primary goals of the Bioinformatics Core are to assist researchers, faculty and students from all participating institutions by: offering bioinformatics educational opportunities; providing research opportunities and support; facilitating interdisciplinary and inter-institutional collaborations, providing infrastructure support, and supporting online library resources. The specific aims include the provision of 1) education opportunities through course development and delivery, workshops and seminars; 2) support for research and collaboration by assisting researchers in managing their research data, identifying tools for in silico analysis, creating bioinformatics workflows and utilizing a cyber- infrastructure that supports collaborative groups; 3) a secure, robust and easily accessible cyber-infrastructure; and 4) an online library resource for SD BRIN. Bioinformatics underlies acquisition and analysis of proteomics, genomics and genetics data. Therefore, the services provided by the Bioinformatics Core are critical to the maintenance and growth of the SD BRIN biomedical research endeavors of faculty throughout the network, and meet the growing needs of bioinformatics skills in several domains of biomedical research. The impact on public health is the advancement of research in areas such as disease progression and the development of novel drugs to treat infection. Several action steps have been proposed to accomplish these aims. Innovative activities and systems such as the creation of curricula amenable to distance learning, the creation of a Bioinformatics Learning Portal, and implementation of novel workflow management systems greatly facilitate bioinformatics education of undergraduate and graduate students as well as faculty, and support the sharing of data, analytic tools and scientific workflows. In collaboration with the University of Nebraska at Omaha (and NE-INBRE) Bioinformatics workshops will be developed and delivered to PUI undergraduate students and mentors. Bioinformatics personnel will assist the SD BRIN research cores, faculty and students with the identification, installation and execution of analytic tools appropriate to meet their data acquisition, storage and analysis needs. A High Performance Computing environment (created in INBRE Phase I), high-capacity redundant network storage for data generated by the Proteomics and Genomics cores, and research data servers provided to the PUI partner researchers will continue to be supported. Finally, SD BRIN will continue to provide library support and access to a large number of scientific journals through the SD BRIN supported library databases and resource access. Bioinformatics support will result in enhancement of the biomedical research capabilities and increased productivity of SD BRIN faculty and students network wide.