FASEB SRC on Ion Channel Regulation

 描述（由申请人提供）：这是第七届两年一度的FASEB离子通道调节科学研究会议部分支持的申请。本次会议的目标是激发话语，播种新的想法，并以加速离子通道在基础和翻译水平上的新发现的方式激发合作。占人类基因的约1.5%，离子通道受到许多致病突变的影响。有超过55种遗传性疾病归因于编码离子通道的基因突变。这些"通道病"影响大脑（例如，癫痫、偏头痛、共济失调），心脏（例如，心律失常），和其它组织（例如，听力和视力障碍、囊性纤维化、肌肉疾病）。毫不奇怪，离子通道是治疗心律失常、癫痫和神经性疼痛的主要药物靶点。离子通道的失调与癌症和精神疾病密切相关，这两者都是深刻的全球健康问题。因此，我们会议的主题对于广大科学家，临床医生和公众来说既及时又高度相关。2015年会议的联合主席将是Amy Lee博士（爱荷华州大学）和Peter Mohler博士（俄亥俄州州立大学），他们都是离子通道生物学领域公认的领导者，重点是通道调节。该方案包括九次科学会议、一次主旨发言和一次题为"妇女在科学领域的挑战和机遇"的小组会议。大多数会议是围绕一般主题而不是离子通道亚型组织的，以促进传统会议中通常保持分离的领域之间的串扰。几个计划中的会谈集中在罕见疾病（通道病）的分子和细胞基础上。将有36名会议发言人进行全面演讲，其中包括14名妇女（占发言人的39%）和9名会议主席（其中5名妇女，占55%）。大多数受邀的演讲者在前两次会议上都没有在这次会议上发言。在36位会议发言人中，我们计划包括6位早期职业阶段的调查人员和6位在科学领域代表性不足的少数民族成员（17%），这些数字将在从提交的摘要中选出的8个简短演讲中得到支持;我们还将与来自历史上资金不足的国家的机构合作在西方鼓励他们的参与，从而鼓励新的合作。会议场地为残疾人与会者提供了适当的设施。

 DESCRIPTION (provided by applicant): This is an application for partial support of the 7th biennial FASEB Science Research Conference on Ion Channel Regulation. The objective of this conference is to stimulate discourse, seed new ideas, and stimulate collaboration in ways that will accelerate new discoveries about ion channels at the basic and translational levels. Accounting for ~1.5% of human genes, ion channels are subject to numerous disease-causing mutations. There are more than 55 inherited disorders that are attributed to mutations in genes encoding ion channels. These "channelopathies" affect the brain (e.g., epilepsy, migraine, ataxia), the heart (e.g., cardiac arrhythmia), and other tissues (e.g., hearing and vision impairment, cystic fibrosis, muscle disease). Not surprisingly, ion channels are major drug targets in the treatment of cardiac arrhythmia, epilepsy, and neuropathic pain. Dysregulation of ion channels is strongly associated with cancer and mental illness, both of which are profound global health concerns. Thus, the topic of our conference is both timely and highly relevant for a broad population of scientists, clinicians, and the general public. The Co-chairs of the 2015 conference will be Dr. Amy Lee (University of Iowa) and Dr. Peter Mohler (Ohio State University), both recognized leaders in ion channel biology with an emphasis on channel regulation. The Program consists of nine scientific sessions, 1 keynote address, and a panel session titled "Challenges and Opportunities for Women in Science". Most sessions were organized around general themes rather than ion channel subtype, to foster crosstalk between fields typically kept separate in traditional conferences. Several of the planned talks focus upon the molecular and cellular basis of rare diseases (channelopathies). There will be 36 session speakers giving full talks, including 14 women (39% of speakers) and 9 session chairs (5 of whom are women, 55%). Most of the invited speakers have not presented at this conference during the prior two meetings. Of the 36 session speakers, we are planning to include 6 early career stage investigators and 6 members of under- represented minorities in science (17%), numbers that will be bolstered in 8 short talks to be selected from submitted abstracts; we will also work with institutions from historically underfunded states the within the West to encourage their participation, thereby encouraging novel collaborations. The conference venue has appropriate facilities for disabled attendees.