Epidemiology, Prevention, and Treatment of Influenza and Other Respiratory Infect

描述（由申请人提供）：在马拉维一个疟疾高度流行和艾滋病毒高流行的地区，确定与流感（和其他呼吸道病原体）相关的严重急性呼吸道感染（SARI）在城市和农村高风险成人和儿童中的性质和程度。在流感病毒流行的背景下，这项工作将把重点放在1岁以下儿童、孕妇和艾滋病毒感染的成年人身上，这些成年人患有或没有疟疾，住在马拉维城市（布兰太尔）的一家大型中心医院和农村地区（奇赫瓦瓦）。位于疟疾高负担的Cikhwawa的一个多产妇产妇研究设施靠近位于Blantyre的多产妇产妇主要实验室，这为比较农村和城市以及疟疾高流行人群和低流行人群提供了一个独特的机会。

DESCRIPTION (provided by applicant): To define the nature and extent of influenza (and other respiratory pathogens) associated Severe Acute Respiratory Infection (SARI) amongst urban and rural high-risk adults and children in Malawi in an area with highly endemic malaria and a high HIV prevalence. In the context of circulating influenza viruses, this work will focus SARI amongst those children under 1 year old, pregnant mothers and HIV infected adults admitted with and without malaria to a large Central Hospital in urban Malawi (Blantyre) and a rural site (Chikhwawa). The proximity of a MLW research facility based in Cikhwawa with a high malaria burden to the main MLW laboratory in Blantyre, provides a unique opportunity to make comparisons between rural and urban, and high and low malaria endemic populations.