2016 Barriers of the CNS Gordon Research Conference & Gordon Research Seminar

项目摘要/摘要 该提案要求支持为2016年的《中枢神经障碍》提供部分资金 系统(CNS)的GRC和GRS将于6月18日至19日在新罕布夏州科尔比·索耶学院举行， 2016年(GRS)和2016年6月19日至24日(GRC)。这次国际会议的总体目标是增加 了解中枢神经系统屏障在健康和健康中的结构和功能的基本机制 疾病。2016年的会议将展示前沿研究，并就以下各方面提供新的视角 中枢神经系统阻碍了科学。围绕神经血管单位和主要屏障系统的概念，如 血脑屏障、血脑脊液屏障和血视网膜屏障将全面治理 在专题演讲和每日海报会议中进行了探讨。会议的具体主题将涵盖以下主要方面 包括转运蛋白在内的中枢神经系统障碍，神经疾病和疾病的影响，免疫学，新 方法、药物输送和该领域的未来。 该计划将包括2场开场主题演讲，主题是与独特中枢神经系统相关的新视角 疾病状态下的血管生态位、神经血管调节和功能障碍以及最后的主题演讲 关于CNS壁垒中与学术/产业伙伴关系相关的挑战和机遇的讲座 科学。另外8场会议将讨论以下具体主题：运输、信号和交汇点 中枢神经系统屏障及其以外；中风和脑损伤中的屏障功能；神经退行性变中的屏障功能 疾病和脑癌；中枢神经系统屏障和相关系统的免疫学；成像和模型系统； 中枢神经系统药物的投放和分销；以及关于如何最大限度地扩大 学术团体和行业团体之间的合作，并促进该领域的合作科学。 GRC填补了一个关键的利基市场，否则这在其他主要国际组织中是不存在的 以及国家会议，将来自不同领域和国家的科学家和临床医生聚集在一起 重点讨论中枢神经系统障碍，扩大对关键问题的理解，从分子 药物输送机制。之前为期两天的“障碍”GRS是由初级调查人员在 博士后水平，旨在介绍更年轻的科学家(研究生、博士后、初级 教师)对该领域的方法和问题进行培训，并促进建立联系和提供指导机会。 这个GRC专注于中枢神经系统障碍科学的高翻译性领域。此应用程序具有一个 与健康的重要关系，因为演讲和讨论将扩大我们对所有人的理解 中枢神经系统障碍的一些方面，包括它们在中枢神经系统疾病中的发育和功能改变。洞察力 所获得的成果将有助于我们未来在认识障碍和哪些因素制约方面取得重大进展 它们刺激了从模型到人类的新应用程序的开发，而且，重要的是， 确定新的战略，以改进神经疾病的诊断、预防和治疗。

Project Summary / Abstract This proposal requests support for partial funding of the 2016 `Barriers of the Central Nervous System (CNS)' GRC and GRS that will be held at Colby Sawyer College, New Hampshire, on June 18 – 19, 2016 (GRS) and June 19 – 24, 2016 (GRC). The overall goal of this international conference is to increase understanding of the basic mechanisms underlying the structure and function of CNS barriers in health and disease. The 2016 meeting will present cutting-edge research and provide new perspectives on all aspects of CNS barriers science. Concepts surrounding the neurovascular unit and major barrier systems such as the blood-brain barrier (BBB), blood-cerebrospinal fluid barriers and blood-retinal barriers will be comprehensively explored in featured talks and daily poster sessions. Specific themes for the meeting will cover key aspects of the CNS barriers including transporters, the effects of neurological disorders and disease, immunology, novel methods, drug delivery, and the future of the field. The program will include 2 opening keynote lectures on new perspectives associated with unique CNS vascular niches and neurovascular regulation and dysfunction in disease states as well as a final keynote lecture on challenges and opportunities associated with academic/industrial partnerships in CNS barriers science. An additional 8 sessions will address the following specific topics: transport, signaling and junctions at the CNS barriers and beyond; barrier function in stroke and brain trauma; barrier function in neurodegenerative disease and brain cancer; immunology of the CNS barriers and related systems; imaging and model systems; CNS drug delivery and distribution; and evolving perspectives on how to maximize partnerships among and between academic and industry groups and promote collaborative science in the field. The Barriers GRC fills a critical niche which otherwise does not exist among other major international and national conferences to bring together scientists and clinicians from diverse fields and countries for a focused meeting on the CNS barriers, expanding understanding of key issues ranging from molecular mechanisms to drug delivery. The preceding 2-day “Barriers” GRS is organized by junior investigators at the postdoctoral level and is intended to introduce younger scientists (postgraduate students, post-docs, junior faculty) to the field's methods and issues and to facilitate networking and provide mentorship opportunities. This GRC is focused on the highly translational area of CNS barriers science. This application has a significant relationship to health, in that the presentations and discussions will expand our understanding of all aspects of the CNS barriers, including their development and altered function in CNS diseases. The insights gained will facilitate significant future progress in our appreciation of the barriers and what factors regulate them, stimulate the development of new applications extending from models to human beings, and, importantly, identify novel strategies to improve the diagnosis, prevention, and treatment of neurological disorders.