Joint Biology Consortium Resource-based Center

项目摘要/摘要--总体 打破翻译研究的障碍是找到治疗炎症性关节炎新方法的关键 在成人和儿童身上。因此，我们提出了联合生物学联盟(JBC)，这是一个共享的基础设施 总部设在布里格姆妇女医院、波士顿儿童医院和布罗德研究所，以加速 一个专注于关节炎的研究社区在美国和国外的17个研究中心开展的工作。三 围绕联合专家委员会成员的共同需求设计的核心将提高现有研究的效率， 促进创新，培养初级调查人员。 1.行政核心是JBC的组织核心，协调业务，培养 JBC研究网络的科学潜力。JBC协同会议促进科学交流和 JBC网络门户促进了通信和服务的交付。JBC浓缩 该计划纳入了获奖导师的创新，通过Grant支持JBC青年调查员 AIMS审查，一个新的指导计划，以及小额赠款，以使JBC的核心服务得以利用。 2.人体生物样本核心为成人和儿童生物样本提供“一站式购物” 关节炎研究。基于网络的搜索和有针对性的门诊招聘将转变多个不同的 将BWH和儿童医院的资源整合到生物谱系及其相关的临床和遗传学的统一管道中 数据。 3.蜂窝系统核心为关节炎研究提供资源和专业知识密集型工具。钥匙 服务包括集中的人体样本处理、细胞周期分析、单细胞和低输入rna-seq以及 创新的HoxB8技术核心，用于临床前模型细胞的生成和CRISPR/Cas9操作， 包括中性粒细胞、单核细胞和破骨细胞。 由坚定的关节炎研究人员带头，主任彼得·尼格罗维奇博士和副主任彼得·尼格罗维奇博士。 伊丽莎白·卡尔森，JBC将在一个包容和高度协作的高级官员网络中刺激创新 和初级研究人员，领导联合生物学联盟成为翻译研究的引擎 成人和儿童关节炎。

PROJECT SUMMARY/ABSTRACT - Overall Breaking down barriers to translational research is the key to finding new approaches to inflammatory arthritis in adults and children. We therefore propose the Joint Biology Consortium (JBC), a shared infrastructure based at the Brigham and Women's Hospital, Boston Children's Hospital, and the Broad Institute to accelerate the work of an arthritis-focused Research Community at 17 research centers in the US and abroad. Three Cores designed around the shared needs of JBC members will enhance the efficiency of existing studies, facilitate innovation, and foster junior investigators. 1. The Administrative Core is the organizational heart of the JBC, coordinating operations and cultivating the scientific potential of the JBC research network. The JBC Synergy Meeting promotes scientific interchange and collaboration, while the JBC Web Portal facilitates communication and service delivery. The JBC Enrichment Program, incorporating innovations from award-winning mentors, supports JBC Young Investigators via grant aims review, a novel mentoring program, and microgrants to enable utilization of JBC core service. 2. The Human Biosamples Core provides “one stop shopping” for adult and pediatric biospecimens essential to arthritis research. Web-based searches and targeted in-clinic recruitment will transform multiple distinct resources at BWH and Children's into a unified pipeline for biospecimens and associated clinical and genetic data. 3. The Cellular Systems Core provides resource- and expertise-intensive tools for arthritis research. Key services include centralized human sample processing, CyTOF, single-cell and low-input RNA-seq, and an innovative HoxB8 technology core for generation and CRISPR/Cas9 manipulation of pre-clinical model cells, including neutrophils, monocytes, and osteoclasts. Spearheaded by committed arthritis researchers Director Dr. Peter Nigrovic and Associate Director Dr. Elizabeth Karlson, the JBC will spur innovation within an inclusive and highly collaborative network of senior and junior investigators, leading the Joint Biology Consortium to become an engine of translational research in adult and pediatric arthritis.