Mouse Pathobiology: Models of Human Disease

描述(由申请人提供)：这项机构T-32培训补助金(RR07073)提案寻求资金，以继续为兽医(DVM或VMD)和DVM/博士提供出色的环境，以获得特定的研究和概念技能，以有效地利用人类疾病的小鼠模型。对于训练有素的现代翻译研究方法的熟练科学家来说，应用医学的进步来改善人类健康是非常需要的。自2002年以来，通过出色的招聘和利用资源，该培训计划已招收了20名DVM加入计划。在该计划前9年资助的20名学员中，8人获得了NIH K、TL1或F奖，13人已被录取并受雇于生物医学或学术职位，其余人即将完成培训。所有被招募到该项目的兽医都有出色的学术背景和研究经验。新的培训教师和课程赞扬了经验丰富的导师，他们在最先进的分子和细胞技术方面培训兽医科学家，系统地评估对公共健康重要的人类疾病实验小鼠模型的病理生物学。培训计划通过俄亥俄州立大学(OSU)、兽医学院、比较和兽医研究生项目进行协调；该项目是美国最全面的健康科学中心的组成部分。培训计划的具体目标包括：1)学员将获得知识和技能，通过教学课程和病理学和分子生物学的应用培训，充分了解和评估人类疾病的小鼠模型的病理生理变化；2)学员将与我们的多学科教员互动，以确定使用小鼠和其他啮齿动物模型的研究问题的途径；3)学员将熟悉参与教员的实验室和临床现场正在进行的基础和临床研究研究，并选择一个利用小鼠或啮齿动物模型进行终点评估的研究问题；4)在选定教师和研究问题后，学员将参与实验的设计和执行，以及数据的分析和呈现。这些具体目标支持T-32计划的总体目标，即支持学员获得分子生物学、遗传学、病理学、实验动物医学和研究设计方法论方面的广泛背景。培训人员代表了一群经验丰富的基础和临床科学家，他们在俄亥俄州立大学和全国儿童医院的多个部门的合作项目中有良好的培训记录。作为这一培训计划的结果，学员将全面了解基于假设的研究，并获得必要的知识和技能，以满足国家在培养与人类健康相关的老鼠病理生物学方面的熟练科学家方面的需求。

DESCRIPTION (provided by applicant): This institutional T-32 training grant (RR07073) proposal seeks funds to continue an outstanding environment for veterinarians (DVM or VMD) and DVM/PhDs to acquire specific research and conceptual skills to effectively utilize mouse models of human disease. Significant need exists for skilled scientists trained in modern translational research methods to apply advances in medicine to improve human health. The training program has enrolled 20 DVMs into the program since 2002 through outstanding recruitment and leverage of resources. Of the 20 trainees supported over the first 9 years of the program, 8 were awarded NIH K, TL1, or F Awards and 13 have matriculated and are employed in biomedical or academic positions and the remaining are on track to complete their training. All veterinarians recruited into the program have outstanding academic backgrounds and established records of research experiences. New training faculty and courses compliment experienced mentors who train veterinarian scientists in state-of-the-art molecular and cellular techniques to systematically evaluate the pathobiology of experimental mouse models of human disease important to public health. The training program is coordinated through The Ohio State University (OSU), College of Veterinary Medicine, Graduate Program in Comparative and Veterinary Medicine; an integral component of the most comprehensive health sciences center in America. The Specific Aims of the training program include: 1) trainees will gain knowledge and skills to fully understand and evaluate pathophysiologic alterations of murine models of human disease through both didactic coursework and applied training in pathology and molecular biology; 2) trainees will interact with our multidisciplinary faculty to identify the rane of research problems that use murine and other rodent models; 3) trainees will acquaint themselves with the ongoing basic and clinical research studies in the laboratories and clinical sites of the participating faculty, and select a research problem that utilizes a murine or rodent model for endpoint evaluation; and 4) following the selection of a preceptor and research problem, trainees will participate in the design and performance of experiments, as well as analysis and presentation of data. These specific aims support the overall goal of the T-32 Program to support trainees to acquire a broad background in molecular biology, genetics, pathology, laboratory animal medicine, and research design methodology. Training faculty represent an experienced group of basic and clinical scientists with strong training records from collaborative programs in multiple departments at OSU and Nationwide Children's Hospital. As a result of this training program, trainees will gain a comprehensive understanding of hypothesis-based research and gain knowledge and skills required to fulfill national needs in the development of skilled scientists in mouse pathobiology relevant to human health.