NICHD Materal Fetal Medicine Units Network

描述（由申请人提供）：伯明翰亚拉巴马大学（UAB）母胎医学部提交本申请，以更新我们作为Eunice Kennedy Shriver NICHD母胎医学单位（MFMU）网络临床中心的参与。我们提出我们中心目前的卓越表现记录，并指定新的属性和计划，以增加我们的贡献网络的目标，调查在临床产科的主要问题，特别是那些有关低出生体重，早产，和妊娠的医疗并发症。我们拥有完善的研究基础设施和在MFMU网络内外进行相关临床试验的丰富经验。作为过去四个五年周期的网络参与中心，UAB在指导委员会和小组委员会层面为网络提供研究方向方面发挥了领导作用，有效地促进了网络试验的开展，并积极参与了这些试验产生的数据的介绍和出版。在该网络历史上的28个临床中心中，UAB研究者是MFMU网络180篇出版物中约25%的第一作者。在全国会议上，该网络总共作了360次发言，其中22%是由一名UAB调查员作的发言。UAB调查小组的现任成员积累了超过150人年的积极参与或支持MFMU研究项目的经验。Alan Tita，MD，PhD和William Andrews，PhD，MD将继续担任PI和候补。该团队包括两名以前的研究中心PI和5名曾担任网络协议主席或小组委员会成员的成员。最后，根据患者招募、方案依从性、保留和随访、数据质量和研究启动时间，MFMU网络数据协调中心将我们在77%（10/13）的参与中心中排名第1或第2（总体排名第1，58%）。如果在这一竞争性的续期申请中成功，我们将调动我们的设施，设备，数据管理系统（包括我们的电子围产期记录系统），招聘资源，强大的调查团队和训练有素的人员，甚至更多的开发和实施MFMU网络协议和项目。我们相信，在未来五年内，我们作为NICHD MFMU网络中心的竞争性更新仍然处于有利地位。

DESCRIPTION (provided by applicant): The Maternal-Fetal Medicine Division of the University of Alabama at Birmingham (UAB) submits this application to renew our participation as a clinical center of the Eunice Kennedy Shriver NICHD Maternal- Fetal Medicine Units (MFMU) Network. We present our center's current record of exceptional performance and specify new attributes and plans to increase our contributions to the Network's goals of investigating major problems in clinical obstetrics, particularly those related to low birth weight, prematurity, and medical complications of pregnancy. We have a well-established research infrastructure and extensive experience in performing relevant clinical trials both within and outside the MFMU Network. As a Network participating center over the last four 5-year cycles, UAB has played a leadership role in providing research direction for the Network at the Steering Committee and sub-committee levels, contributed efficiently to the conduct of Network trials, and participated significantly in the presentation and publication of data generated by these trials. Among 28 clinical centers in the history of the Network, a UAB investigator has first-authored approximately 25% of 180 current MFMU Network publications. Of 360 total Network presentations at national meetings, a UAB investigator presented 22%. Current members of the UAB investigative team have accumulated well over 150 person-years experience of active participation in or support of MFMU research projects. Alan Tita, MD, PhD and William Andrews, PhD, MD will continue as PI and Alternate. The team includes two previous site PI's and 5 members who have served as Network protocol chairpersons or Subcommittee members. Finally on the basis of patient recruitment, protocol adherence, retention and follow-up, data quality, and study start-up time, the MFMU Network Data Coordinating Center ranked us #1 or #2 among the participating centers 77% (10/13) of the time (#1 overall, 58% of the time). If successful in this competitive renewal application, we will marshal our facilities, equipment, data management systems (including our electronic perinatal record system), recruitment resources, strong investigative team and trained personnel even more to develop and implement MFMU Network protocols and projects. We believe that we remain well positioned for competitive renewal as an NICHD MFMU Network center for the next five years.