UT Southwestern NCI National Clinical Trials Network Lead Academic Site - U10

描述(由申请人提供)：德克萨斯大学西南医学中心(UTSW)有领导、转化性研究和合作团体试验的历史。这笔赠款的获奖者是Joan Schiller博士，他是血红素/肿瘤科主任和 西蒙斯癌症中心(SCC)副主任，ECOG胸科委员会前主席，现任UTSW主要机构ECOG Grant的PI。共同调查人员包括UTSW放射肿瘤科主任、RTOG疾病部位副主席和RTOG胸科委员会前主席Hak Choy博士；GOG董事会成员和子宫语料库委员会主席David Miller博士；ACOSOG执行委员会成员Marilyn Leitch博士；以及美国癌症学会前主席、ACRIN乳房委员会创始成员之一、曾担任UTWW ACRIN赞助试验首席研究员的Phil Evans博士。2012年，UTSW在成人合作组试验中招募了105名患者。自2006年以来，UTSW的教职员工调查或合作调查了96篇合作小组出版物和85篇摘要，并主持、联合主持或担任了34项合作小组试验的合作委员会主席。UTSW也是美国国立卫生研究院定量成像卓越中心的网站。UTSW是达拉斯/堡垒唯一的学术医学中心和医学院。沃斯(DFW)Metroplex是美国第四大大都市区，也是德克萨斯州北部唯一一家NCI指定的癌症中心。UTSW还拥有强大的临床和过渡性研究计划和药物发现计划；肺癌的孢子；高级成像研究中心；并可接触到不同的民族和种族人口。在DFW Metroplex，大约10.3%的被诊断为癌症的人群是西班牙裔，14.1%是非裔美国人；2012年，接受合作小组临床研究的SCC患者中，29.6%是西班牙裔，13.6%是非裔美国人后裔。UTSW UIO的具体目标是通过招募具有不同民族和种族背景的患者参加治疗和非治疗试验来促进和促进NCTN；(2)NCTN的科学方向，通过将UTSW进行的基础、翻译和成像研究纳入假说驱动的临床试验。(3)多学科的努力和跨多学科和多个合作小组的合作；(4)通过主持和联合主持临床试验和委员会，以及通过参与NCI的活动和倡议，发挥领导作用；以及(5)初级教师的职业发展。

DESCRIPTION (provided by applicant): The University of Texas Southwestern Medical Center (UTSW) has a history of leadership, translational research, and accrual to cooperative group trials. The PI of this grant is Dr. Joan Schiller, chief of the Division of Heme/Oncology and Deputy Director of the Simmons Cancer Center (SCC), former Chair of ECOG's Thoracic Committee and currently PI of UTSW's main institution ECOG grant. Co-investigators include Dr. Hak Choy, Chair of UTSW's Department of Radiation Oncology, Vice Chair for Disease Sites in RTOG, and former Chair of RTOG's Thoracic Committee; Dr. David Miller, member of the GOG Board of Directors and Chair of the Uterine Corpus Committee; Dr. Marilyn Leitch, member of the Executive Committee of ACOSOG, and Dr. Phil Evans, immediate past president of the American Cancer Society, who was one of the founding members of the ACRIN Breast committee, and served as the principal investigator at UTSW for ACRIN sponsored trials. In 2012, UTSW enrolled 105 patients on adult co-operative group trials. Since 2006, UTSW faculty have investigated or co-investigated 96 co-operative group publications and 85 abstracts, and have chaired, co-chaired, or served as cooperative committee chair on 34 cooperative group trials. UTSW is also a site for the NCI Centers Quantitative imaging Excellence. UTSW is the only academic medical center and medical school in the Dallas/Ft. Worth (DFW) Metroplex, the fourth largest metropolitan area in the country, and is the only NCI designated Cancer Center in north Texas. UTSW also has a strong clinical and transitional research program and drug discovery program; a SPORE in lung cancer; an Advanced Imaging Research Center; and has access to a diverse ethnic and racial population. In the DFW Metroplex, roughly 10.3% of the populations with a cancer diagnosis are Hispanic, and 14.1% are African American; in 2012, 29.6% of SCC patients going on co-operative group clinical studies were of Hispanic ethnicity, and 13.6% were of African American ancestry. The specific aims of the UTSW UIO are to contribute to and promote: (1) The NCTN by enrolling patients with diverse ethnic and racial background on therapeutic and non-therapeutic trials; (2) The scientific direction of the NCTN by bringing the basic, translational, and imaging research conducted at UTSW into hypothesis driven clinical trials. (3) Multidisciplinary efforts and collaboration across multiple disciplinesand multiple cooperative groups; (4) Service in leadership roles by chairing and co-chairing clinical trials and committees, and by participating in NCI activities and initiatives; and (5) The career development of junior faculty.