Biostatistics

项目摘要/摘要：生物统计学共享资源(BSR) 生物统计共享资源(BSR)的目标是确保为 具有成本效益的研究设计和开发、数据管理以及数据分析和解释 亚利桑那大学癌症中心(UACC)所有研究项目的方式。BSR还提供 根据需要创新统计设计方法，以确保UACC调查人员实现他们的科学 目标。这种支持是通过团队方法和特定BSR的长期专注参与来促进的 所有四个UACC研究计划中嵌入的人员。BSR教职员工通力合作 参与构思、设计、实施、分析和报告/手稿准备 在UACC内进行的实验室、转译、临床和基于人群的研究。BSR 提供以下服务：1)为个人科学目标和专业知识量身定制的广泛咨询 (有经验的研究人员与早期研究人员；临床研究背景与基础研究背景)；2)统计考虑 用于资助申请(将科学目标转化为可统计检验的假设，样本量/ 权力论证和制定统计分析计划)；3)统计分析和列报 (从短期统计咨询到长期合作参与正在进行的研究 项目)；4)监测正在进行的研究进展(应计报告、数据完整性和结果 确定)；5)数据管理(使用OnCore和RedCap)；6)临床方案制定(样本 规模论证和制定适当的统计分析方法)；7)协助编制 手稿和报告；8)按科学审查服务对UACC议定书进行的统计审查 委员会；9)通过数据和安全监测服务监测研究安全和数据完整性 理事会；10)教育和培训(包括在为临床研究员举办的讲习班和为 UACC研究计划)。BSR成员在设计和分析中发挥着至关重要的作用，也在 调查人员为他们的研究问题制定逻辑框架，并帮助确保有效的解释 结果的结果。

Project Summary / Abstract: Biostatistics Shared Resource (BSR) The goal of the Biostatistics Shared Resource (BSR) is to ensure excellent and timely biostatistical support for study design and development, data management, and data analysis and interpretation in a cost-effective manner for all Research Programs of the University of Arizona Cancer Center (UACC). BSR also provides innovative approaches to statistical design, as needed, to ensure UACC investigators achieve their scientific goals. This support is facilitated by a team approach and the long-term dedicated involvement of specific BSR personnel embedded within all four of the UACC Research Programs. BSR faculty and staff are collaboratively involved in the conception, design, implementation, analysis, and reporting/manuscript preparation of laboratory, translational, clinical, and population-based research conducted within the UACC. The BSR provides the following services: 1) extensive consultation tailored to individual scientific goals and expertise (experienced vs. early stage investigator; clinical vs. basic research background); 2) statistical considerations for funding applications (translation of scientific objectives into statistically testable hypotheses, sample size / power justifications, and development of statistical analysis plans); 3) statistical analysis and presentation (from short-term statistical consultations to longer-term collaborative involvement in ongoing research projects); 4) monitoring ongoing study progress (accrual reporting, data completeness, and outcome ascertainment); 5) data management (use of OnCore and REDCap); 6) clinical protocol development (sample size justification and development of an appropriate statistical analysis approach); 7) assistance in preparation of manuscripts and reports; 8) statistical review of UACC protocols by service on the Scientific Review Committee; 9) monitoring study safety and data integrity through service on the Data and Safety Monitoring Board; 10) education and training (including presentations in workshops for clinical fellows and seminars for UACC Research Programs). BSR members play an essential role in design and analysis and also work with investigators to develop a logical framework for their research questions and help to ensure valid interpretation of the results.