On the road to recovery: building Liberia's clinical and epidemiological research capacity to respond to emerging infectious diseases

项目总结/摘要 最近爆发的毁灭性埃博拉疫情暴露出需要加大对卫生和人类健康的投资， 利比里亚的资源。在国家过敏和传染病研究所（NIAID）的支持下， 利比里亚-美国埃博拉病毒研究伙伴关系（PREVAIL）是作为紧急情况制定的， 合作研究奋进进行埃博拉疫苗和治疗药物的临床试验，以帮助结束 患有埃博拉病毒感染。尽管2013-2016年埃博拉疫情已经结束，但此前33年的历史 埃博拉疫情告诉我们，我们必须继续做好准备。加州大学旧金山分校弗朗西斯科 （UCSF）与利比里亚大学（UL）和加州大学洛杉矶分校合作 （加州大学洛杉矶分校），将制定和实施严格的培训计划，在临床和流行病学研究 利比里亚调查人员和卫生专业人员的方法。培训的主要目的是建立能力， 利比里亚人成为能够成功实施高质量临床研究的独立临床研究者 和流行病学研究，解决埃博拉病毒和其他新兴传染病的关键重要领域 疾病最终目标是使UL能够支持其自己的临床研究硕士（MS）学位， 培养和指导了一批训练有素的核心调查人员，他们可以成为 他们的领域。具体来说，我们将招收利比里亚卫生专业人员在加州大学旧金山分校的计划培训临床 研究（TICR）提供严格的临床研究，流行病学，生物统计学，实施 科学和原创研究的分析，并授予为期两年的临床研究硕士学位。程度 需要与PREVAIL合作进行的实际研究培训。PREVAIL科学家 还将共同指导学员沿着与加州大学旧金山分校和加州大学洛杉矶分校的教师。加州大学洛杉矶分校公共卫生学院 在刚果民主共和国开展新发传染病研究和培训的多年经验 来自刚果。该培训计划是基于在加州大学旧金山分校的全球健康科学超过二十年的经验 以及流行病学和生物统计学系，培训国际调查人员，博士后 学者和初级教员。除了提供硕士水平的培训，我们还将提供高级培训 如何成为一个成功的导师，这对培养初级调查人员至关重要，但很少正式 作为撒哈拉以南非洲学术或研究文化的一部分得到支持。此D 71应用程序描述了 制定全球传染病研究培训计划（D43）的规划过程。D43- 资助的培训将加强利比里亚科学家和卫生研究专业人员的能力， 与成功的公众相关的独立、高质量的传染病流行病学和临床研究 应对新出现的传染病的卫生对策。

PROJECT SUMMARY/ABSTRACT The recent and devastating Ebola outbreak exposed the need for greater investment in health and human resources in Liberia. Supported by the National Institute of Allergy and Infectious Diseases (NIAID), the Liberian-U.S. Partnership for Research on Ebola Virus (PREVAIL) was developed as an emergency, collaborative research endeavor to conduct clinical trials for Ebola vaccines and therapeutics to help end the suffering from Ebola virus infection. Although the 2013-2016 Ebola outbreak is over, the history of 33 prior Ebola outbreaks tells us that we must continue to prepare. The University of California, San Francisco (UCSF), in collaboration with the University of Liberia (UL), and the University of California, Los Angeles (UCLA), will develop and implement a rigorous training program in clinical and epidemiological research methods for Liberian investigators and health professionals. The primary aim of training is to build the capacity of Liberians to become independent clinical investigators who can successfully implement high-quality clinical and epidemiologic research addressing key areas of importance in Ebola virus and other emerging infectious diseases. The eventual goal is to enable UL to support its own Master's (MS) Degree in Clinical Research by having nurtured and mentored a core group of well-trained investigators who can in turn become leaders in their field. Specifically, we will enroll Liberian health professionals in UCSF's program Training in Clinical Research (TICR) that provides rigorous training in clinical research, epidemiology, biostatistics, implementation science and analysis of original research, and confers a two-year MS Degree in Clinical Research. The degree requires practical research training that will be performed in collaboration with PREVAIL. PREVAIL scientists will also co-mentor trainees along with UCSF and UCLA faculty. The School of Public Health at UCLA brings many years of experience with emerging infectious disease research and training in the Democratic Republic of Congo. The training plan is based on over two decades of experience at UCSF's Global Health Sciences and the Department of Epidemiology & Biostatistics, in training international investigators, post-doctoral scholars, and junior faculty. In addition to providing Master's level training, we will also offer advanced training in how to be a successful mentor, which is critical to nurturing junior investigators, but is rarely formally supported as part of the academic or research culture in sub-Saharan Africa. This D71 application describes the planning process for developing a Global Infectious Disease Research Training Program (D43).The D43- funded training will strengthen the capacity of scientists and health research professionals in Liberia to conduct independent, high-quality infectious disease epidemiologic and clinical research relevant to a successful public health response to emerging infectious diseases.