High School Student NeuroResearch Program (HSNRP)

摘要 亚利桑那大学（UA）高中生神经研究计划（HSNRP） 介绍，培训和培养一个不断增长的管道多样化的人才亚利桑那州高中 学生，扩大了选择进步的本科生，包括大多数 在基础、转化和临床研究中代表性不足的弱势少数群体 正常和异常的神经系统，神经系统疾病和中风，也鼓励 追求先进的研究经验和履行健康/医疗/科学相关的职业生涯。 我们正在利用强大的基础设施，有效的招聘策略，高水平的 我们的学生/教师导师参与，团队精神和杰出的学员生产力 长期联邦资助的多学科/多专业弱势高中 学生，本科生和医学生暑期研究项目和全年 丰富活动，为这个专门的神经研究（NR）的培训模型注入活力 程序. 14 -16名全日制8-12周暑期高中和4-6名本科学员 在未来5年，每年将提供一个不断扩大的菜单，密切指导NR 经验;为保留在管道中，选择HSNRP学员将随后 更先进的NR。通过相互交流，这些学员将融入 一个创新的，国际公认的基于调查的医学无知暑期研究所 （SIMI）交织生物医学已知和未知（“我们知道我们不知道， 我不知道我们不知道，并认为我们知道，但不”）与特色NR主题和导师 “故事”，并通过全年定期丰富活动保持势头。西米 强调“翻译翻译和科学质疑”，包括简介 病理生物学和医学语言，专题研讨会，实验室/领导/ 多媒体技能研讨会和实习，临床相关性，社交网络和职业生涯 建议。一个独特的虚拟临床研究中心/附属设备构成了一部移动的电话 可访问的核心平台，用于培训和国家/国际网络。在基本 临床部门和专业卓越中心， 由充满活力、经验丰富的多学科HSNRP领导团队负责 和咨询委员会，学生的研究将包括跨领域的主题，并在体内， 体外、原位、计算机模拟和神经生物学/疾病（包括帕金森病）的建模方法， 阿尔茨海默病、尼曼-皮克C病、ALS、癫痫、HIV脑病、头部创伤， 脑积水、肌肉萎缩症、疼痛/成瘾药理学、分子精神病学， 认知，脑发育，脑地形图，衰老，智力低下，血脑 屏障/神经保护，神经影像学，神经基因组学/蛋白质组学，神经工程，深 脑刺激、脑肿瘤、脑血管疾病、中风、神经健康差异，以及 康复活动.基于我们约29年的跟踪记录和建立的访问大型多样化 615名接受SIMI培训的高中生反映了亚利桑那州弱势学生群体 迄今为止，许多基础/临床神经研究（本科生/研究生/ 专业学位/生物医学健康职业）管道，我们预计HSNRP将继续 培养一个不断扩大的多元化和好奇的研究人员，医生和其他健康网络 专业人士;有助于神经研究管道和企业;并提高 通过社区参与进行“神经健康”扫盲。正在进行的短期和长期 评价包括调查、数据库登记、“好奇心”量表、短期和长期跟踪， 和职业组合，以记录培训模式的有效性和可持续性， 多样性和国家/国际网络。

ABSTRACT The University of Arizona (UA) High School Student NeuroResearch Program (HSNRP) introduces, trains, and nurtures a growing pipeline of diverse talented Arizona high school students, expanded by select progressing undergraduates, including a majority of underrepresented disadvantaged minorities in basic, translational, and clinical research on the normal and abnormal nervous system, neurological disorders, and stroke, and also encourages pursuit of advanced research experiences and fulfilling health/medical/science-related careers. We are leveraging the strong infrastructure, effective recruitment strategies, high level of student/faculty mentor participation, esprit-de-corps, and outstanding trainee productivity of our long-standing federally funded multidisciplinary/multispecialty disadvantaged high school student, undergraduate, and medical student summer research programs and year-round enrichment activities to energize the training model for this specialized NeuroResearch (NR) program. Fourteen-16 full-time 8-12 week summer high school and 4-6 undergraduate trainees annually for the next 5 years will be offered an expanding menu of closely mentored NR experiences; for retention in the pipeline, select HSNRP trainees will be subsequently reappointed for more advanced NR. Interacting together, these trainees will be integrated into an innovative, internationally recognized inquiry-based Summer Institute on Medical Ignorance (SIMI) which interweaves biomedical Knowns and Unknowns ("what we know we don't know, don't know we don't know, and think we know but don't") with featured NR topics and mentor "stories" and sustains the momentum by periodic enrichment activities year-round. SIMI emphasizes "translating translation and scientific questioning" and includes a brief Introduction to Pathobiology and the language of medicine, topical seminars, laboratory/leadership/ multimedia skill workshops and practicums, clinical correlations, social networking, and career advising. A unique Virtual Clinical Research Center/Questionarium forms a mobile phone accessible-centerpiece platform for training and national/international networking. Within basic and clinical departments and specialized Centers of Excellence with enhanced Neuroscience emphasis and overseen by an energetic experienced multidiscplinary HSNRP Leadership Team and Advisory Committee, student research will encompass cross-cutting themes and in vivo, in vitro, in situ, in silico, and modeling approaches to neurobiology/disorders including Parkinson, Alzheimer, Niemann-Pick C diseases, ALS, epilepsy, HIV encephalopathy, head trauma, hydrocephalus, muscular dystrophy, pain/addiction pharmacology, molecular psychiatry, cognition, brain development, brain mapping, senescence, mental retardation, blood-brain barrier/neuroprotection, neuroimaging, neuro-genomics/proteomics, neuroengineering, deep brain stimulation, brain tumors, cerebrovascular disease, stroke, neurohealth disparities, and rehabilitation. Based on our ~29-year track record and established access to large diverse pools of disadvantaged Arizona students reflected in 615 SIMI-trained high school students followed to date with many in the basic/clinical NeuroResearch (undergraduate/graduate/ professional degree/biomedical-health career) pipeline, we expect HSNRP to continue to cultivate an expanding network of diverse and curious researchers, physicians and other health professionals; contribute to the NeuroResearch pipeline and enterprise; and improve "neurohealth" literacy through community engagement. Ongoing short-term and long-term evaluation includes surveys, database registry, "curiosity" scales, short- and long-term followup, and career portfolios to document efficacy and sustainability of the training model, promote diversity, and national/international networking.