Workshop on Techniques in Modeling Human Cancer in Mice

描述(申请人提供)：癌症是一组基因复杂和生物异质性的疾病。越来越清楚的是，实验室小鼠是人类最好的基因定义的实验模式生物，它为理解癌症的遗传基础和潜在生物学提供了一个快速进步的重大机会。我们课程的总体目标是培训一小群年轻科学家(博士前、博士后实习生和新的研究人员)使用基因定义的实验室小鼠作为遗传工具，询问关于基因功能和遗传学在癌症生物学中的作用的问题。完成这门课程的学生将获得如何描述和分析特定的老鼠癌症模型的实用知识。选择的模型将反映几个器官部位，包括结肠、前列腺、乳房、肺、皮肤、血液和大脑。这门课程将包括上午的授课课程，介绍特定的器官部位以及与这些器官部位相关的癌症的特征，然后是密集的实验室课程，学生将获得操作和分析相关老鼠模型的实践经验。课程将包括固定和活细胞成像技术、细胞学、肿瘤植入的外科方法和病理学。这些目标将通过向16名因其杰出的研究潜力而被选中的年轻调查人员提供为期10天的强化课程来实现。他们将与来自杰克逊实验室和其他著名机构的一群著名的老鼠遗传学家和癌症生物学家进行互动。班级规模将被故意保持在较小的水平，以实现理想的师生互动水平，并 允许学生进行广泛的实验室培训和实践。该课程将于每年10月份在杰克逊实验室的住宅海滨会议设施HighSea举行。讲座、讨论、工作坊和演示将在上午、下午和晚上举行，总共约72小时的授课和动手培训。我们要求在此应用程序中提供整整五年的支持。杰克逊实验室是美国国家癌症研究所指定的基础研究癌症中心，在举办高级课程和科学会议方面有着悠久的历史。

DESCRIPTION (provided by applicant): Cancer is a genetically complex and biologically heterogeneous group of disorders. It has become increasingly clear that the laboratory mouse, the best genetically defined experimental model organism for humans, presents a major opportunity for rapid advancement in understanding the genetic basis and underlying biology of cancer. The overall goal for our course, "Workshop on Techniques in Modeling Human Cancer in Mice", is to train a small group of young scientists (predoctoral, postdoctoral trainees, new investigators) in the use of genetically defined laboratory mice as genetic tools for asking questions about gene function and the role of genetics in the biology of cancer. Students completing the course will acquire a practical knowledge of how to characterize and analyze specific mouse cancer models. The models chosen will reflect several organ sites including colon, prostate, mammary, lung, skin, blood and brain. The course will consist of didactic lectures in the morning to introduce particular organ sites and the characteristics of cancers associated with those organ sites, followed by intensive laboratory sessions whereby students will gain hands on experience in the manipulation and analysis of relevant mouse models. Sessions will include fixed and live cell imaging techniques, cytometry, surgical approaches to the implantation of tumors, and pathology. These Aims will be accomplished by offering an intensive 10-day course to 16 young investigators chosen for their outstanding research potential. They will interact with a group of prominent mouse geneticists and cancer biologists both from The Jackson Laboratory and other prominent institutions. The size of the class will be kept deliberately small in order to achieve a desirable level of student-faculty interaction and to permit extensive laboratory training and practice for the students. The course will be held annually during the month of October at Highseas, The Jackson Laboratory's residential oceanfront conference facility. Lectures, discussions, workshops, and demonstrations will be held morning, afternoon, and evening for a total of approximately 72 hours of didactic and hands-on training. We are asking for a full five years of support in this application. The Jackson Laboratory is an NCI-designated Basic Research Cancer Center and has a long history of hosting advanced courses and scientific meetings.