Neuropathology Core

项目概要/摘要：神经病理学核心 神经病理学核心是一致的，以支持OADC的5个首要目标的总体具体目标：1） 通过一个组织，促进和维持AD和相关疾病的创新研究和发现， 支持丰富协作环境的基础设施; 2）将资源集中于 强调：临床前痴呆和疾病活动，强调最古老的老年人;有意义的 通过外周生物标志物、神经影像学和持续的家庭行为研究捕获的变化 监测;脑老化和老年痴呆症的神经病理学;新疗法的新测试;以及 改善有关痴呆症的教育和知识; 3）提供材料，通过良好的科学支持， 特征化的研究参与者、生物标本、脑组织、数据提供和分析; 4） 促进与AD和相关疾病相关的国家研究共享;以及5）提供场地， 教育和培训新科学家的机制，以及教育和告知主要利益攸关方。 OADC神经病理学核心的重点是从健康老龄化到痴呆症的过渡， 从认知完整的大脑捐赠者和那些发展中国家的大脑捐赠者中积累大量组织， 老年痴呆症和较轻的损伤，病理学与老年痴呆症和较轻的损伤有所不同， 典型的老年痴呆症在临床和影像学发现的背景下理解这些变化 在这些人中，被提议作为科学的主旋律，围绕着这个主题构建了具体的目标。 这些目标是： 1.提供标准化的研究评估，同时提供这种诊断专业知识， OADC受试者人群，提供死者家属和参与 根据最新的标准化诊断标准及时提供尸检报告。 2.通过收集、存储和分发一个高度可访问的、但适当的 保护，精心准备的脑组织和神经病理学数据的储存库， 纵向特征的轻度认知障碍（MCI）或痴呆患者以及非 认知障碍的个人使用各种方法，最大限度地利用科学家。 3.向病理学、神经学、心理学、精神病学和基础科学的受训者传授当前的方法 神经退行性疾病和年龄相关变化的神经病理学分类，以及导师 在NP中学习。 4.制定创新的新方法，最大限度地实现目标1至3。

Project Summary/Abstract: Neuropathology Core� The Neuropathology Core is aligned to support the overall specific aims of the OADC's 5 overarching aims: 1) catalyze and sustain innovative research and discovery in AD and related disorders through an organizational infrastructure supporting a rich collaborative environment; 2) focus resources toward specific areas of emphasis: preclinical dementia and activity of disease emphasizing the oldest old; markers of meaningful change captured through studies of peripheral biomarkers, neuroimaging and continuous in-home behavioral monitoring; neuropathology of brain aging and late life dementia; novel testing of novel treatments; and improving education and knowledge about dementia; 3) provide materials to support the science through well- characterized research participants, biological specimens, brain tissue, data provision and analytics; 4) contribute to the national research commons relevant to AD and related disorders; and 5) provide venues and mechanisms for education and training of new scientists, as well as educating and informing key stakeholders. The focus of the OADC's Neuropathology Core on the transition from healthy aging to dementia has led to the accumulation of a large repository of tissue from cognitively intact brain donors and from those who develop dementia and milder impairments at a more advanced age, with pathologies that differ somewhat from those of classic Alzheimer's disease. Understanding these changes in the context of the clinical and imaging findings in these individuals is proposed as the scientific leitmotif around which the Specific Aims are constructed. These are to: 1. Provide standardized research assessments while at the same time affording this diagnostic expertise to the population of OADC subjects by providing family members of the deceased and physicians involved in their care with timely autopsy reports based on the most current standardized diagnostic criteria. 2. Facilitate research by collecting, storing and distributing a highly accessible, but appropriately safeguarded, repository of well-prepared brain tissue and neuropathologic data from carefully and longitudinally characterized patients with mild cognitive impairment (MCI) or dementia as well as non- cognitively impaired individuals using a variety of methods that maximizes utility to scientists. 3. Teach trainees in pathology, neurology, psychology, psychiatry, and basic sciences the current methods of neuropathological classification of neurodegenerative diseases and age-related changes, and mentor faculty in NP. 4. Develop innovative new approaches to maximize achievements in Aims 1 to 3.