Decision Science Core

决策科学核心摘要 德克萨斯农工大学超级基金研究中心将调查环境影响 从源头到结果的整个过程中与紧急情况有关的污染事件，包括命运和 运输、对人类健康的危害，以及减少污染和毒性。为了实现该中心的 改善环境紧急情况后决策的最终目标，得出的结论 这些项目需要对急救人员、受影响的社区和政府机构进行解释 参与现场管理和清理工作。因此，整个中心将得到一项决定的支持 科学核心，它拥有合成相关科学数据和结论的专业知识，供 参与与风险管理相关的决策。决策科学核心的总体目标是 提供新颖的建模服务，以支持项目结果的凝聚力、相关性和实施 在环境决策的背景下。由德克萨斯农工大学的邱伟学博士执导， 在与北卡罗来纳大学教堂山分校的格雷戈里·查拉克利斯博士的合作下，核心将 在三个具体目标下为中心研究人员提供多种方法和服务将有助于 中心项目之间的互动，同时也是连接社区参与核心和 研究翻译核心。提供的主要服务将包括毒物动力学模型(目标1)、人类健康 风险建模(目标2)和经济建模(目标3)。在目标1中，毒物动力学模拟服务将是 提供给项目以推断暴露剂量与细胞或组织中的内部浓度之间的关系， 考虑到化学物质的吸收、分布、代谢和排泄。毒物动力学模型是一种 在使用体外分析评估危险和风险方面迈向新范式的关键部分。在目标2中， 人类健康风险模型将用于对人类人口中的危险或风险进行推断 以实验或观测数据为基础的，作为科学数据和 环境政策决策。在超级基金的背景下，人类健康风险建模用于 证明暴露标准或环境补救决定既保护人类健康又 降低毒性或风险。在目标3中，将提供成本和效益的经济模型，作为对 环境政策决策，从规划和优先事项的设定到建立环境补救或 曝光标准。提供具有成本效益的环境解决方案不仅对以下方面具有重要意义 政府机构，但也向受影响的社区和利益攸关方提供援助，其中许多人将至少承担 直接或间接的一些成本。作为一个整体，这些建模服务将支持中心的 总体目标是帮助解释研究项目结果，并将其转化为可供 不同的利益相关者，从社区到联邦和州决策者，评估人类健康和 环境紧急情况后污染物暴露的经济影响，并加强规划， 紧急反应，以及与环境灾害有关的长期恢复和补救工作。

Decision Science Core ABSTRACT The Texas A&M University Superfund Research Center will investigate the impacts of environmental emergency-related contamination events across the source-to-outcome continuum, including fate and transport, human health hazard, and mitigation of contamination and toxicity. In order to achieve the Center's ultimate goal of improving decision-making after an environmental emergency, the conclusions drawn from these projects will need to be interpretable to first responders, impacted communities, and government bodies involved in site management and cleanup. Therefore, the entire Center will be supported by a Decision Science Core, which has expertise in synthesizing relevant scientific data and conclusions for use by those involved in decisions related to risk management. The overall objective of the Decision Science Core is to provide novel modeling services for supporting the cohesion, relevance, and implementation of project findings in the context of environmental decision-making. Directed by Dr. Weihsueh Chiu at Texas A&M University and in collaboration with Dr. Gregory Characklis at the University of North Carolina at Chapel Hill, the Core will provide numerous methods and services to the Center researchers under three specific aims will facilitate interaction among Center projects, while also serving as a bridge to the Community Engagement Core and Research Translation Core. Key services provided will include toxicokinetic modeling (Aim 1), human health risk modeling (Aim 2), and economic modeling (Aim 3). In Aim 1, toxicokinetic modeling services will be provided to the projects to extrapolate between exposure doses and internal concentrations in cells or tissues, taking into account chemical absorption, distribution, metabolism, and excretion. Toxicokinetic modeling is an essential part of moving towards a new paradigm in evaluating hazard and risk using in vitro assays. In Aim 2, human health risk modeling will be used to make inferences about hazard or risk in the human population based on experimental or observational data, serving as an essential bridge between scientific data and environmental policy decisions. In the context of Superfund, human health risk modeling is used to demonstrate that exposure standards or environmental remediation decisions both protect human health and reduce toxicity or risk. In Aim 3, economic modeling of costs and benefits will be provided as a key input into environmental policy decisions, from planning and priority setting to establishing environmental remediation or exposure standards. The delivery of cost-effective environmental solutions is of keen interest not only to government agencies, but also to affected communities and stakeholders, many of whom will bear at least some of the cost, either directly or indirectly. As a whole, these modeling services will support the Center's overall goal by helping to interpret and translate research project findings into information that can be used by varied stakeholders, from communities to federal and state decision-makers, to assess the human health and economic impact of contaminant exposures after an environmental emergency, and enhance the planning, emergency response, as well as long-term recovery and remediation efforts related to environmental disasters.