The Effects of Spironolactone on Inflammation in a Rodent Model of Pulmonary Arterial Hypertension

本研究的第一部分已经完成。在过去的一年里，我们继续在啮齿动物心脏导管插入术和心脏磁共振成像方面发展必要的技术技能。为了提高右心室功能评估的分辨率和准确性，我们将心脏磁共振成像作为方案的一部分，而不是超声心动图。研究的第二部分，确定螺内酯与依普利酮的影响，于2017年5月开始，我们已经完成了第一组实验。

Part 1 of this study has been completed. Over the past year, we have continued to develop the necessary technical skills in rodent cardiac catheterization and cardiac magnetic resonance imaging. We have implemented cardiac resonance imaging as part of the protocol instead of echocardiography in order to improve both the resolution and precision of our assessments of right ventricular function. Part 2 of the study, determining the effects of spironolactone versus eplerenone, began in May 2017 and we have completed the first set of experiments.