2016 Proteoglycans Gordon Research Conference & Gordon Research Seminar

 描述（由申请人提供）：该提案要求对将于2014年7月10日至15日在新罕布什尔州安多弗市普罗克特学院举行的戈登蛋白聚糖研究会议提供部分支持。大会自1984年起每两年举办一次，享有盛誉。它汇集了一群不同的研究人员，他们将在一个紧张而非正式的环境中展示关于蛋白聚糖的新的和未发表的高影响力研究。会议将由科学组织委员会选出的特邀演讲者组成，该委员会包括前蛋白聚糖戈登会议主席和其他具有大量蛋白聚糖研究专业知识的人。除了聚集高水平的蛋白聚糖研究科学家外，会议还为新的研究人员提供了一个论坛，让他们在海报会议上展示自己的工作，或者在某些情况下，作为受邀演讲者进行简短的演讲，这些演讲与核心受邀演讲者之间相互交织。戈登会议设置为所有与会者提供了一个独特而有效的方式来密切互动。延长的讨论以及 普罗克特学院组织良好的田园环境为与会者提供了与演讲者直接互动的充分机会，因此他们可以获得对最新研究成果的更多见解，同时促进新合作的形成。蛋白聚糖领域以其合议、公开讨论和对初级研究人员的支持而闻名。最初会议主要集中在软骨和关节炎。然而，随着时间的推移，蛋白聚糖在许多生物系统中具有关键功能，包括肌肉骨骼系统的许多部分如肌肉，骨骼，肌腱和牙齿的形成和病理学。除了它们在骨骼中的功能之外，蛋白聚糖在免疫学和炎症、血管形成、心脏功能、癌症和发育中具有基本作用。蛋白聚糖在这些系统中的作用为设计治疗与它们相关的常见疾病的疗法提供了关键基础，这些研究领域将是拟议会议的重点。蛋白聚糖也被证明在罕见疾病中起关键作用，如多发性遗传性外生骨疣和粘多糖病，这两种疾病都将在该计划中强调。今年将增加两个新的会议，将解决：1）蛋白聚糖在衰老和慢性疾病中的作用，2）蛋白聚糖在生物工程和再生医学中的应用。蛋白聚糖会议是非常国际化的，超过40%的与会者来自欧洲，亚洲，南美和澳大利亚。与会者将通过邀请从网上提交的申请中选出，并将被选择代表不同的研究人员，并将认真关注妇女和代表性不足的少数民族在会议的各个方面，包括讨论领导人，演讲者，海报展示者和与会者的包容性。

 DESCRIPTION (provided by applicant): The proposal requests partial support for the Gordon Research Conference on Proteoglycans that will be held on July 10-15, 2014 in Proctor Academy, Andover, NH. The conference has been held every two years since 1984 and has an outstanding reputation. It brings together a diverse group of investigators who will present new and unpublished high impact research on proteoglycans in an intense yet informal setting. The conference will be composed of invited speakers chosen by a scientific organizing committee that includes former Proteoglycan Gordon Conference Chairs and others who have substantial research expertise proteoglycans research. In addition to assembling high level proteoglycan research scientists the conference provides a forum for new investigators to present their work in poster sessions or, in some cases, as invited speakers to give short talks that are intertwined between the core set of invited speakers. The Gordon conference setting provides a unique and effective way for all of the attendees to closely interact. The extended discussions as well as the well-organized pastoral setting at Proctor Academy gives attendees ample opportunity for direct interaction with speakers so they can gain additional insight into the latest research findings and, at the same, facilitate the formation of new collaborations. The proteoglycan field is well-known for its collegiality, open discussions, and support of junior investigators. Originally the conference focused primarily on cartilage and arthritis. However over time it became clear that proteoglycans have critical functions in numerous biological systems including the formation and pathology of many parts of the musculoskeletal system such as muscle, bone, tendons and teeth. In addition to their function in the skeleton the proteoglycans have fundamental roles in immunology and inflammation, vascularization, cardiac function, cancer and development. The roles of proteoglycans in these systems has provided a pivotal foundation for devising therapy to treat common diseases associated with them and these research areas will be the focus of the proposed conference. Proteoglycans have also been shown to have key roles in rare diseases such as multiple hereditary exostoses, and mucopolysaccaridosis both of which will highlighted in the program. This year two new sessions will be added that will address: 1) the role of proteoglycans in aging and chronic disease and 2) applications of proteoglycans to bioengineering and regenerative medicine. The Proteoglycan conference is very international with over 40% of the attendees coming from Europe, Asia, South American and Australia. Attendees will be selected by invitation from the applications submitted online and will be chosen to represent a diverse set of researchers and careful attention will be paid to the inclusion of women and underrepresented minorities in all aspects of the conference including Discussion Leaders, Speakers, Poster Presenters and Attendees.