Comp C-Urological Managment of Newborns with Spina Bifida

描述（由申请人提供）：脊柱裂是脊髓和相关椎骨的主要先天性异常。它的发病率大约是每1000个新生儿中有1个，目前在美国的临床患病率超过7万人。这是最常见的先天缺陷，会导致多器官系统的严重残疾。脊髓损伤对神经系统、骨科和泌尿系统有许多有害影响。新生儿脊柱裂的泌尿学评估始于出生。尽管普遍认为婴儿早期泌尿系统管理的重要性，但多年来，关于什么形式的管理是最合适的，一直存在重大争议。本研究的目的是，利用一个定义良好的最佳实践协议，进行一项超过5年的多机构研究

DESCRIPTION (provided by applicant): Spina bifida is a major congenital anomaly of the spinal cord and the associated vertebrae. It has an incidence of roughly 1 per 1000 births and a current clinical prevalence of greater than 70,000 people in the United States. It is the most common birth defect that results in severe disability of multiple organ systems. The spinal cord lesion has numerous deleterious effects on the neurologic, orthopedic and urologic systems. Urological evaluation of infants with spina bifida begins at birth. Despite universal agreement on the importance of early urological management of the infant, for some years there has been a major controversy as to what form of management is most appropriate. The aim of this research is, utilizing a well defined best practices protocol, to conduct a multi-institutional study over 5 years to determine the most appropriate form of urologic management in infants born with spina bifida. The purpose of the research is also to assess numerous functional outcome measures at the end of the study period including specific measurements of renal function and bladder dynamics.