Pharmacokinetic Physiologic Modeling in Simultaneous PET/MR

项目摘要 PET和MRI提供了互补的生理学观点，并能够测量这两种模式的数据 同时提供了一个独特的机会来研究生物机制，在此之前 在完好的动物身上是不可能实现的，包括人类受试者。然而，硬件和数据方面的这种进步 由于以下事实，采集给数据分析和解释带来了新的挑战 基于不同的物理原理，一般反映不同的活体现象。从概念上讲，我们 通过集成的PET/MR分析框架解决问题并抓住机遇，其中共享 生理机制将定量PET和MR模型数学联系起来，提高了准确性和 生理测量的精确度，以及在一些情况下，允许使用 两种方式都不能单独使用。这一通用方法是针对几个具体的和说明性的开发而提出的 病例--神经传递、线粒体膜电位和氧化应激--一起跨越 不同的器官系统、生理过程和潜在的疾病应用。

Project Summary PET and MRI offer complementary views of physiology and the ability to measure data from both modalities concurrently provides a unique opportunity to study biological mechanisms in ways that were heretofore impossible to realize in intact animals, including human subjects. However, this advance in hardware and data acquisition poses new challenges for data analysis and interpretation due to the fact that the modalities are based upon different physical principles and generally reflect different in vivo phenomena. Conceptually, we address the problem and seize the opportunity via integrated PET/MR analysis frameworks wherein shared physiological mechanisms mathematically link quantitative PET and MR models, improving the accuracy and precision of physiological measurements and, in several instances, permitting outcomes not achievable using either modality alone. This general approach is proposed for development in several specific and illustrative cases – neurotransmission, mitochondrial membrane potential, and oxidative stress – that together span diverse organ systems, physiological processes, and potential disease applications.